摘要
目的探究乙酰半胱氨酸对慢性阻塞性肺疾病(COPD)急性加重期患者肺功能、血清炎性因子及抗氧化指标水平的影响。方法选取江苏省无锡市人民医院2015年9月至2017年9月收治的COPD急性加重期患者154例。按照随机数字表法分为对照组和观察组,各77例。对照组行COPD常规治疗,观察组在对照组基础上辅以乙酰半胱氨酸600 mg/次,1~2次/d口服治疗,2组均治疗1周。比较2组治疗前后肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV_1)、第1秒用力呼气容积占用力肺活量百分比(FEV_1/FVC)]、血清炎性指标[高敏C反应蛋白(hs-CRP)、降钙素原]及抗氧化指标[丙二醛、超氧化物歧化酶(SOD)、谷胱甘肽]水平。结果治疗后观察组FVC、FEV_1、FEV_1/FVC指标均高于对照组[(2.87±0.22)L比(2.64±0.54)L、(2.65±0.33)L比(1.71±0.45)L、(67±7)%比(59±7)%],差异均有统计学意义(均P<0.05)。治疗后观察组血清hs-CRP、降钙素原水平均低于对照组[(4.6±2.4)mg/L比(9.4±3.8)mg/L、(0.31±0.26)μg/L比(0.92±0.55)μg/L],差异均有统计学意义(均P<0.05)。治疗后观察组丙二醛水平低于对照组,SOD、谷胱甘肽水平高于对照组[(4.1±0.6)μmol/L比(7.3±0.7)μmol/L、(82±7)μg/L比(71±7)μg/L、(162±12)U/L比(128±13)U/L],差异均有统计学意义(均P<0.05)。结论乙酰半胱氨酸应用于COPD急性加重期患者治疗中可有效改善其肺功能,提高机体抗氧化水平,抑制炎症反应,促进肺功能恢复。
ObjectiveTo investigate the effect of acetylcysteine on pulmonary function, serum inflammatory factors and antioxidant indexes in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. MethodsA total of 154 patients with acute exacerbation of COPD admitted from September 2015 to September 2017 in Wuxi People′s Hospital were randomly divided into control group and observation group, with 77 cases in each group. The control group were treated with conventional therapy; the observation group took acetylcysteine 600 mg/time, 1-2 times/d on the basis of conventional therapy for 1 week. Lung function indexes[forced vital capacity（FVC）, forced expiratory volume in 1 second（FEV1）, FEV1/FVC], serum inflammatory factors[high-sensitivity C-reactive protein（hs-CRP）, procalcitonin] and antioxidant indexes[malondialdehyde, superoxide dismutase（SOD）, glutathione] were analyzed before and after treatment. ResultsAfter treatment, FVC, FEV1 and FEV1/FVC in observation group were significantly higher than those in control group[（2.87±0.22）L vs （2.64±0.54）L, （2.65±0.33）L vs （1.71±0.45）L,（67±7）% vs （59±7）%]（P〈0.05）; serum levels of hs-CRP and procalcitonin in observation group were significantly lower than those in control group[（4.6±2.4）mg/L vs （9.4±3.8）mg/L, （0.31±0.26）μg/L vs （0.92±0.55）μg/L]（P〈0.05）; serum level of malondialdehyde in observation group was significantly lower, serum levels of SOD and glutathione were significantly higher than those in control group[（4.1±0.6）μmol/L vs （7.3±0.7）μmol/L, （82±7）μg/L vs （71±7）μg/L, （162±12）U/L vs （128±13）U/L]（P〈0.05）. ConclusionAcetylcysteine treating acute exacerbation of COPD can effectively inhibit inflammatory response, increase antioxidation and improve pulmonary function recovery.
作者
张林
范晓东
许红阳
Zhang Lin1, Fan Xiaodong2, Xu Hongyang3(1Department of Emergency, Wuxi People＇ s Hospital, Jiangsu Province, Wuxi 214023, China; 2Department of Respiratory Medicine, Waxi People＇s Hospital, Jiangsu Province, Wuxi 214023, China ; 3Intensive Care Unit, Wuxi People＇s Hospital, Jiangsu Province, Wuxi 214023, Chin)
出处
《中国医药》
2018年第7期1016-1020,共5页
China Medicine
基金
江苏省卫生和计划生育委员会科研课题(BJ15009)~~
关键词
慢性阻塞性肺疾病
乙酰半胱氨酸
肺功能
高敏C反应蛋白
降钙素原
Chronic obstructive pulmonary disease
Acetylcysteine
Pulmonary function
High-sensitivity C-reactive protein
Procalcitonin
作者简介
通信作者：范晓东，Email：xqqhar@163．com
