摘要
鼻咽癌在广东省等华南地区多发，晚期患者生存率低。血管生成与鼻咽癌的生长、转移和侵袭密切相关，鼻咽癌的全部外显子和基因组测序研究报道了几种可行的治疗靶点，抗血管生成药物治疗鼻咽癌也逐渐成为众多研究的热点。特异高效阻断血管生成，将是未来用“精准医学”策略治疗鼻咽癌的主要发展方向之一。因此，抗血管生成药物和其他抗癌策略如化学疗法联合的个性化疗法对鼻咽癌患者的最佳治疗及结果来说是必不可少的。
Nasopharyngeal carcinoma （NPC） is a common disease in SouthChina, including Guangdong Province. Advanced patients usually have a low survival rate. Angiogenesis is closely related to the growth, metastasis and invasion of nasopharyngeal carcinoma. Whole exome and genome sequencing （WES, WGS） researches of NPC have posted some viable therapeutic targets, Anti-angiogenesis drugs treating nasopharyngeal carcinoma have gradually become the focus of many studies, Specific and efficient blockage of angiogenesis will be one of the main developmental directionsin future use of ＂precision medicine＂ strategies for the treatment of nasopharyngeal carcinoma. Therefore, Personalized therapy that combining anti-angiogenic drugs and other anticancer strategies such as chemotherapy, appears essential for optimal outcome in nasopharyngeal carcinoma patients.
作者
王宇洋
段鸿芳
聂国辉
Wang Yuyang;Duan Hongfang;Nie Cruohui(Graduate School Guangzhou Medical University, Guangzhou 511436, China;Department of Otolaryngology, Shenzhen Children＇s Hospital Shenzhen 518038, China;Department of Otolaryngology, Shenzhen Second People＇s Hospital, Shenzhen 518035, China)
出处
《国际耳鼻咽喉头颈外科杂志》
2018年第3期161-165,共5页
International Journal of Otolaryngology-Head and Neck Surgery
基金
深圳市科技研发基金（JCYJ20170413162242627）
关键词
鼻咽肿瘤
血管生成抑制剂
药物疗法
Nasopharyngeal Neoplasms
Angiogenesis Inhibitors
Drug Therapy
作者简介
通信作者：聂国辉，Email．nghui@21cn．com
