摘要
目的采用Meta分析探讨超声心动图左心室正常测量值的异质性来源。方法计算机检索PubMed、Embase、Medline等数据库2005年1月至2017年9月关于研究健康成年人超声心动图左心室正常测量值的文献。采用Cohrane’s Q检验，并以I^2为统计量检验异质性，采用亚组分析、敏感性分析和Meta回归分析异质性来源。结果检索获得9篇文献包含5933例研究对象纳入研究，异质性检验显示左心室解剖结构各测量值在各研究间均存在较大异质性。按种族差异进行亚组分析，部分测值组内异质性显著降低。Meta回归分析显示部分测值种族归因异质性占比较高。结论左心室解剖结构正常测量值异质性主要与种族差异性有关，但种族差异不能完全解释研究间的异质性，仍需进一步研究左心室解剖结构正常测量值异质性的参与因素。
Objective To investigate the echocardiography mesurements by Meta analysis heterogeneity of the left ventricular reference value in Methods A literature retrieval in PubMed, Embase, Medline and other databases from January 2005 to September 2017 related to left ventricular normal reference value in healthy adults was performed. Cohrane＇s Q test was used to test the heterogeneity, and 12 was used as a statistic for the description of heterogeneity. Subgroup analysis, sensitivity analysis and Meta regression were used to analyze the sources of heterogeneity. Results The Meta analysis enrolled 9 studies including 5 933 normal cases. The heterogeneity test showed that the left ventricular normal reference value of echocardiography was highly heterogeneous among the studies. In subgroup analysis, some measurements＇ heterogeneity were significantly reduced. Meta regression analysis showed that the contribution of racial specificity to heterogeneity was relatively high in some measurements. Conclusions The heterogeneity of left ventricle is mainly related to racial specificity, but it cannot fully explain the heterogeneity between studies. Further studies are needed to demonstrate the involved factors of heterogeneity of left ventricular normal reference values.
作者
李益萍
尹立雪
张梅
王斯佳
姚桂华
邓燕
李爽
张运
Li Yiping;Yin Lixue;Zhang Mei;Wang Sijia;Yao Guihua;Deng Yah;Li Shuang;Zhang Yun(Southwest Medical University, Luzhou 646000, Chin)
出处
《中华超声影像学杂志》
CSCD
北大核心
2018年第5期369-374,共6页
Chinese Journal of Ultrasonography
基金
国家自然科学基金（81671852,30970698）
国家重点研发计划（2017YFC0113902）
关键词
超声心动描记术
心室功能
左
参考值
异质性
META分析
Echocardiography
Ventricular function
left
Reference values
Heterogeneity
Metaanalysis
作者简介
通信作者：尹立雪，Email：yinlixue_cardiac@163．com；;张运，Email：zhangyun@sdu．edu．cn
