摘要
目的:观察和比较桑杏二陈汤(SEG)与孟鲁司特钠治疗儿童感染后咳嗽(PIC)的临床有效性及安全性。方法:选择2015年3月~2017年5月就诊于西京医院儿科门诊的PIC152例患儿,将其分为观察组(76例)与对照组(76例)。观察组患儿口服SEG治疗1周,而对照组口服孟鲁斯特钠咀嚼片治疗1周。比较两组患者治疗前后的咳嗽症状积分和疗效。结果:治疗1周后,观察组(SEG组)患儿的咳嗽症状积分与治疗前相比明显下降(P<0.05),而对照组患儿的咳嗽症状积分与治疗前比无明显变化(P>0.05),观察组患儿咳嗽积分明显低于对照组(P<0.05)。观察组患儿的治愈率、显效率均高于对照组(P<0.01)。两组均无不良反应发生。结论:SEG治疗儿童PIC的临床疗效明显优于孟鲁司特钠,且无不良反应发生。SEG治疗可缩短部分PIC患儿的病程。
Objective： To study the clinical efficacy and safety of Sangxingerchen granule（SEG） in the treatment of post-infection cough（PIC） in children. Methods： A prospective randomized controlled study was conducted in 152 cases of PIC children in the pediatric outpatient of Xijing Hospital from March 2015 to May 2017. They were assigned to the treatment group（76 cases） and controlled group（76 cases）. Patients in the treatment group were given SEG orally for 1 week, while patients in the controlled group were given Montelukast chewable tablets for 1 week. Then the cough scores and efficacy were compared between the two groups. Results： After taking 1 week of SEG, the cough scores in the treatment group were significantly decreased compared with those before treatment（P 0.05）,while the cough scores in the control group showed no significant decrease（P〈0.05）. After treatment, the cough scores of treatment group were significantly decreased compared with the control group（P〈0.05）. Both the recovery rate and excellence rate were higher in the treatment group than those in the control group（P〈0.01）. No adverse events was observed in both groups. Conclusion： SEG therapy was better than Montelukast in the treatment of PIC children with no serious adverse reactions, it could shorten the PIC course in part of children with PIC.
作者
李瑞婷
齐瑞
罗剑锋
王爱丽
张月萍
LI Rui-ting;QI Rui;LUO Jian-feng;WANG Ai-li;ZHANG yue-ping(Department of Pediatrics, the Air force Medical University in Xijing Hosptial, Xi＇an, Shaanxi, 710032, China;Department of Pediatn＇cs, Xi＇an 141 hospital, Xi＇an, Shaanxi, 710089, China)
出处
《现代生物医学进展》
CAS
2018年第9期1705-1708,共4页
Progress in Modern Biomedicine
关键词
感染后咳嗽
儿童
桑杏二陈汤
孟鲁斯特钠
Post-infectious cough
Child
Sangxingerchen granule
Montelukast
作者简介
李瑞婷（1988-），硕士研究生，主要研究方向：儿童慢性咳嗽，E-mail：15191815672@163．com;通讯作者：张月萍，主任医师，E-mail：ypzhang@fmmu．edu．cn
