摘要
目的:观察加味瓜蒌薤白半夏汤治疗冠状动脉粥样硬化性心脏病心绞痛痰浊痹阻证的临床疗效及其对患者心肌血运重建的影响。方法:选择2015年9月至2017年10月收治的冠状动脉粥样硬化性心脏病心绞痛痰浊痹阻证患者74例为研究对象,随机分为观察组和对照组,每组各37例。对照组给予单纯西药治疗,观察组在对照组的基础上给予加味瓜蒌薤白半夏汤治疗。比较两组患者的临床疗效,观察两组患者治疗前后心肌血运重建指标及血小板聚集率参数[二磷酸腺苷(adenosine diphosphate,ADP)、胶原(collagen,COL)]的变化情况。结果:观察组有效率为94.59%,对照组有效率为78.38%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后左室前壁中间段的b值与k值高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后COL、ADP低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:加味瓜蒌薤白半夏汤治疗冠状动脉粥样硬化性心脏病心绞痛痰浊痹阻证疗效确切,可有效缓解患者的临床症状,促进心肌血运重建。
Objective： To observe the clinical curative effect of Flavored Trichosanthes and Chinese Chive and Pinellia Decoction on coronary arteriosclerosis porridge heart disease of phlegm stagnation syndrome and its influence on the patients＇ myocardial revascularization. Methods： Seventy-four patients with coronary arteriosclerosis porridge heart disease of phlegm stagnation syndrome who were treated in our hospital between September 2015 and October 2017 were chosen as the research subjects,and randomly divided into the observation group and the control group,with 37 cases in each group. The ones in the control group were treated with Western medicine,while the ones in the observation group received Flavored Trichosanthes and Chinese Chive and Pinellia Decoction based on the treatment of the control group. Then the clinical efficacies of the two groups were compared. And the changes of the myocardial revascularization index,adenosine diphosphate(ADP） and collagen(COL） before and after the treatment of the two groups were observed. Results： The effective rate of the observation group was 94. 59% and that of the control group was78. 38%. The difference between the two groups was statistically significant(P〈0. 05）. The b value and K value of the middle segment of the left ventricle in the two groups were higher than those before the treatment,and the observation group was higher than the control group,and all the differences were statistically significant(P〈0. 05）. After the treatment,the two groups＇ COL,ADP were lower than those before the reatment,and the observation group was lower than the control group,all the differences were statistically significant(P〈0. 05）. Conclusion： Flavored Trichosanthes and Chinese Chive and Pinellia Decoction has a remarkable clinical curative effect on coronary arteriosclerosis porridge heart disease of phlegm stagnation syndrome,can effectively relieve the clinical symptoms of the patients and promote the revascularization of myocardial blood.
作者
裴国宪
PEI Guo-xian(Anyang TCM Hospital, Anyang, Henan, China ,45500)
出处
《河南中医》
2018年第5期668-671,共4页
Henan Traditional Chinese Medicine
关键词
冠状粥脉硬化性心脏病心绞痛
瓜蒌薤白半夏汤
痰浊痹阻证
心肌血运重建
《伤寒论》
张仲景
coronary arteriosclerosis porridge heart disease
Triehosanthes and Chinese Chive and Pinellia Decoction
phlegm stagnation syndrome
myocardial revaseularization
Treatise on Cold Damage Diseases
Zhang Zhong-jing
作者简介
裴国宪（1983-），男，河南安阳人，医学硕士，主治医师。
