摘要
目的分析超敏C反应蛋白(hs-CRP)、胱抑素C(CysC)与2型糖尿病肾病之间的关联性。方法选取收治的2型糖尿病患者120例作为研究对象,将65例单纯糖尿病患者纳入DM组,55例糖尿病肾病纳入DN组,另选取同期健康人60例设为健康组,检测并比较3组血糖相关指标及hs-CRP、CysC水平。结果 DN组UEAR、hs-CRP、CysC水平明显高于DM组与健康组,DM组上述指标同样高于健康组;DM、DN组FPG、2h PG及Hb A1c水平明显高于健康组;DN组hs-CRP阳性率为70.9%,CysC为67.3%,二者联合诊断阳性率为87.3%,均明显高于DM组,均有显著性差异(P<0.05);血清hs-CRP、CysC与UEAR呈正相关(r=0.476,0.741,P<0.05)。结论 hs-CRP、CysC水平与DN间存在明显关联,临床可联合检测以尽早诊治DN。
Objective To analyze the association between hypersensitive C-reactive protein（hs-CRP）, cystatin C（CysC） and type 2 diabetic nephropathy. Methods 120 patients with type 2 diabetes mellitus admitted in our hospital from June 2016 to June 2017 were selected as the subjects. Fifty-six patients with diabetes were included in DM group. Fifty-five patients with diabetic nephropathy were included in DN group. 60 healthy subjects were divided into healthy group, and the levels of blood glucose and hs-CRP and CysC were measured and compared. Results The levels of UEAR hs-CRP and CysC in DN group were significantly higher than those in DM group and healthy group. The level of FPG, 2 h PG and Hb A1 c in DM and DN group was significantly higher than that in healthy group. The expression of hs-CRP in DN group（P〈0.05）. The positive rate was 70.3% and 67.3%, respectively. The positive rate was 67.3%, which was significantly higher than that of DM group（P〈0.05）. Serum hs-CRP, CysC and UEAR showed a positive correlation（r= 0.476,0.741, P〈0.05）. Conclusion The levels of hs-CRP and CysC were significantly correlated with DN, and the clinical diagnosis was possible to diagnose and treat DN as soon as possible.
作者
荣光
卓华钦
叶庆邦
宁海欢
蔡茵瑜
RONG Guang;ZHUO Hua-qin;YE Qing-bang;NING hai-huan;CAI Yin-yu(Third People＇s Hospital of Dongguan City 1.Department of Nephrology;Department of Endocrinology,Dongguan 523326 China)
出处
《现代诊断与治疗》
CAS
2018年第2期171-174,共4页
Modern Diagnosis and Treatment
基金
2017年东莞市社会科技发展项目(一般项目)立项编号201750715024134
关键词
超敏C反应蛋白
胱抑素C
2型糖尿病肾病
关联性
Hypersensitive
C-Reactive Protein
Cystatin C
Type 2 Diabetic Nephropathy
Association
