摘要
目的:探讨还原型谷胱甘肽在急性有机磷农药中毒(AOPP)治疗中的应用价值。方法:选择2013年1月到2016年12月期间经我院急诊科收治入院的170例AOPP患者为研究对象,根据随机数字表法随机分为两组,每组85例,对照组患者予阿托品、氯解磷定等常规治疗,观察组联合应用还原型谷胱甘肽,疗程7d。比较两组患者临床指标及血清胆碱酯酶(CHE)、心肌肌钙蛋白I(c Tn I)的动态变化。结果:入院后24h、3d、7d时,观察组患者CHE明显高于对照组,c Tn I水平均明显低于对照组,差异有统计学意义(P<0.05);观察组阿托品用量、住院时间分别为(258.69±114.27)mg、(10.13±3.24)d,明显少于对照组的(316.52±131.46)mg、(13.75±4.58)d,观察组反跳发生率(3.53%)低于对照组(11.76%),差异均有统计学意义(P<0.05)。结论:还原型谷胱甘肽应用于急性有机磷农药中毒的治疗可有效防治心肌损害,减少阿托品用量,缩短病程。
Objective： To investigate the value of reduced glutathione（ GSH） in the treatment of acute organophosphorus pesticide poisoning（ AOPP）. Methods： 170 AOPP patients treated in the emergency department of our hospital from January 2013 to December 2016 were selected as the research object. According to the random number table method divided into two groups,85 cases in each group,the control group were treated with routine treatment of atropine and pralidoxime chloride,observation group combined with reduced glutathione treatment,treated for 7 days. The clinical parameters and the changes of serum Cholinesterase（ CHE） and cardiac troponin I（ c Tn I） were compared between the two groups. Results： At the 24 h,3 d,7 d,the CHE of the observation group were significantly higher than the control group,and c Tn I were significantly lower,the difference was of statistically significant（ P〈0.05）; the dosage of atropine and hospitalization time in observation group were（ 258. 69 ± 114. 27） mg,（ 10. 13 ± 3. 24） days,significantly less than the control group（ 316.52±131.46） mg,（ 13.75 ± 4.58） days,the observation group rebound rate（ 3. 53%） was lower than in the control group（ 11.76%）,the differences was of statistically significant（ P〈0.05）. Conclusion：The reduced glutathione can be used in the treatment of acute organophosphorus pesticide poisoning,which can effectively prevent myocardial damage and shorten the course of disease.
作者
郭永军
孔媛媛
肖靖华
邓素贞
GUO Yongjun;KONG Yuanyuan;XIAO Jinghua(The Sixth Affiliated Hospital of Guangzhou Medical University,Guangzhou Qingyuan 511518,China)
出处
《河北医学》
CAS
2018年第5期742-744,共3页
Hebei Medicine
基金
广东省卫生厅医学科研基金立项
(编号:B2001125)
关键词
急性有机磷农药中毒
还原型谷胱甘肽
心肌损伤
胆碱酯酶
Acute organophosphorus pesticide poisoning
Reduced glutathione
Myocardial injury
Cholinesterase
