摘要
目的探讨血清抑制性G蛋白α亚基-2(Giα-2)水平在2型糖尿病合并不同分级高血压患者中的改变及临床意义。方法选取197例2型糖尿病患者作为研究对象,分为单纯2型糖尿病(DS)组45例,2型糖尿病合并高血压1级(DH1)组47例,2型糖尿病合并高血压2级(DH2)组51例,2型糖尿病合并高血压3级(DH3)组54例,另选取40例健康人作为健康对照(NS)组。应用酶联免疫吸附法测定血清Giα-2水平。多元线性回归法分析Giα-2水平与各影响因素的相关性。结果 DS组Giα-2水平较NS组降低,DH1、DH2、DH3组Giα-2水平均高于DS组,随着血压增加,Giα-2水平逐渐增加,其中DH3组最高(P<0.05)。多元线性回归分析结果显示Giα-2水平与收缩压呈正相关(r=0.54,P<0.05),进一步多元回归分析提示收缩压是Giα-2水平的独立影响因素。结论 Giα-2可能对2型糖尿病合并高血压的发生有一定的影响。
Objective To investigate the changes and its clinical value of serum Giα-2 in type 2 diabetes and different classification of hypertension. Methods A total of 197 patients with type 2 diabetes were selected into this study,including 45 cases of simple diabetes patients （DS group）,47 cases of diabetic and grade 1 hypertension patients （DH1 group）,51 cases of diabetic and grade 2 hypertension patients （DH2 group） and 54 cases of diabetic and grade 3 hypertension patients （DH3 group）.A total of 40 healthy people were enrolled in this study as normal control （NS group）.The serum Giα-2 level of subjects was detected by ELISA.The relationships of Giα-2 and each influencing factor were analyzed by Multiple Linear Regression. Results The level of Giα-2 in DS group was lower than that in NS group,at the same time,the levels of Giα-2 in DH1,DH2 and DH3 group were higher than that of DS group,and when blood pressure increased,Giα-2 increased,and the highest level of Giα-2 was in DH3 group （ P 〈0.05）.The result of the multivariate linear regression analysis showed that Giα-2 positively correlated with SBP （ r =0.54, P 〈0.05）.Further multiple linear regression analysis showed that Giα-2 level was an independent risk factor of SBP. Conclusion Giα-2 might closely related to the occurrence and development of diabetes and hypertension.
作者
马爽
李宝新
张云良
常文龙
王翯
张鑫
郭淑芹
MA Shuang;LI Baoxin;ZHANG Yunliang;CHANG Wenlong;WANG He;ZHANG Xin;GUO Shuqin(Shool of Gradate,Chengde Medical College,Chengde,Hebei 067000,China;Baoding NO.1 Central Hospital,Baoding,Hebei 071000,China)
出处
《检验医学与临床》
CAS
2018年第9期1217-1219,1223,共4页
Laboratory Medicine and Clinic
基金
国家自然科学基金资助项目(81500644)
河北省医学科学研究重点课题计划项目(20160282)
作者简介
马爽,女,在读硕士,主要从事内分泌与代谢性疾病研究;通信作者,E-mail：gsqnfm＠163.com.
