摘要
目的分析创伤骨科专病中心患者医院感染铜绿假单胞菌分布特点及耐药性变化趋势,指导临床合理使用抗菌药物。方法对2012年1月-2016年12月骨科患者临床分离标本铜绿假单胞菌的监测数据进行回顾分析。结果铜绿假单胞菌感染以伤口感染为主,76.6%的临床标本为伤口分泌物;2012-2016年铜绿假单胞菌的临床检出率总体呈上升趋势(χ~2=38.51,P<0.01);对阿米卡星、庆大霉素、哌拉西林、头孢哌酮、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦和环丙沙星的耐药率均呈现逐年下降趋势;对亚胺培南和美罗培南的耐药率均<25%,且美罗培南较低。结论患者铜绿假单胞菌感染率上升,但对常用抗菌药物耐药率有所下降,说明通过加强抗菌药物的管理、监测细菌耐药变化、严格执行消毒和感染隔离控制以及抗菌药物的联合使用等措施可以延缓耐药的发生。
Objective To analyze the distribution of Pseudomonas aeruginosa and the trend of drug resistance in patients of trauma orthopedic disease center,and to provide the guidance for the rational use of antimicrobial agents. Methods The retrospective study was used to conduct continuous monitoring of Pseudomonas aeruginosa isolated from clinical specimens during January 2012 to December 2016. Results The infection of Pseudomonas aeruginosa mainly occurred in wound,and the clinical samples were mainly wound secretions,that accounted for 76. 6% . Drug resistance of Pseudomonas aeruginosa against Amikacin,Gentamicin,Piperacillin,Cefoperazone,Piperacillin/Tazobactam,Cefoperazone/Sulbatan,and Ciprofloxacin took on the downward trend year by year（ P〈0. 05）; the drug resistance rate of Imipenem and Meropenem was 25% ,and the drug resistance rate of Imipenem was higher than that of Meropenem. Conclusion For patients with trauma orthopedic disease Pseudomonas aeruginosa infection rates rise,but resistance rates to commonly used antimicrobial agents descend,which implies that for the hospital further strengthening the management of antibiotics,monitoring the changes of bacterial resistance,strict disinfection and infection isolation control and the combined use of antimicrobial agents and other related measures may delay the onset of resistance.
作者
江琰笛
JIANG Yan - di(The Sixth Hospital of Ningbo, Ningbo Zhejiang 315000, Chin)
出处
《中国消毒学杂志》
CAS
2018年第3期186-187,191,共3页
Chinese Journal of Disinfection
关键词
骨科
铜绿假单胞菌
感染
抗菌药物
耐药性
orthopedic
Pseudomonas aeruginosa
infection
antimicrobial agents
drug resistance
作者简介
江琰笛（1985-），女，浙江奉化人，本科，主管技师，从事微生物病原学研究。
