摘要
早产儿的血氧饱和度(Sp O2)水平对其健康成长发育有着直接影响,而医护人员手动调节吸入氧气浓度(Fi O2)不但劳动强度大,而且不能保证患儿血氧饱和度长期处于安全范围之内。针对这一临床需求,研制了一套早产儿血氧饱和度自动控制系统,该系统基于PI控制与微分反馈控制。初期临床试验发现,在有手动与自动调节模式切换时以及在对早产儿进行管饲喂养过程中会发生积分饱和现象,导致控制性能恶化。针对这一问题,在原有控制算法的基础上进行了抗积分饱和设计。模拟临床试验结果表明,具有抗积分饱和的控制系统能够实现模式切换的平滑过渡,在患儿进食结束后能够及时降低氧气浓度,从而最大限度地减少患儿血氧饱和度处于安全范围以外的时间。在应对血氧饱和度减饱和现象中,该控制系统能够做出及时准确的调节。模拟临床试验验证了该自动控制系统具备临床可行性,为日后的临床试验奠定了基础。
For premature infants, the Peripheral Oxygen Saturation （SpO2） level has an immediate influence on their health. Manual Fraction of Inspired Oxygen（FiO2） setting by nursing staff is a high labor intensive work and it is also hard to always keep infants＇SpO2 level within the safety range. For this clinical need, an Automated Control System of Peripheral Oxygen Saturation for Premature Infants is developed based on Proportional. Integralcontrol and Derivative Feedback control. The first clinical test shows that there might be Integral Windup happened when there exist Manual-Automatic mode switch and tube feeding. Further, and this will lead to the degradation of control performance. To overcome this problem, an Anti-Windup control strategy is developed based on the old control system. The result of simulated clinical test shows that the Anti-Windup controller could achieve bump-less transfer during mode switch, and reduce FiO2 timely when feeding is finished. Thus, the time that infants＇SpO2 outside the safety range could be minimized. In terms of dealing with SpO2 desaturation events, the automated control system could make instant and accurate adjustment. The simulated clinical test verified that this system has clinical feasibility, and it provides good practice and evidence for future clinical test .
作者
回丽
侯雪丰
Roger Fales
HUI Li;HOU Xuefeng;Roger Fales(College of Electromechanical Engineering, Shenyang Aerospace University,Shenyang 110136, China;Mechanical ＆ Aerospace Engineering, University of Missouri-Columbia, Columbia 65211,USA)
出处
《沈阳航空航天大学学报》
2018年第2期77-81,87,共6页
Journal of Shenyang Aerospace University
作者简介
回丽（1965-）,女,辽宁辽阳人,教授,主要研究方向：航空材料结构强度及完整性评定,E-mail：syhuili＠126.com.
