摘要
多柔比星是一种广谱高效的抗肿瘤药物,但其心脏毒性是限制其临床应用的主要原因之一。多柔比星致心脏毒性的机制尚不完全清楚,通常认为与活性氧增加、线粒体损伤和细胞凋亡等机制相关。细胞自噬是一类依赖于溶酶体的蛋白质降解途径。近年来大量研究证实,自噬在多柔比星所致心脏毒性中具有重要作用。本文主要回顾自噬在多柔比星所致心脏毒性中的作用。
Doxorubicin（Dox） is an effective wide-spectrum antitumor drug. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanisms of cardiotoxicity have not been clearly elucidated, but are known to involve oxidative stress, mitochondrial dysfunction and apoptosis. Autophagy is a lysosome-dependent protein degradation pathway. More recently,many studies have suggested that autophagy plays an important role in Dox-induced cardiotoxicity.This paper gives a systematic review of the role of autophagy in Dox-induced cardiotoxicity.
作者
张升
杨林
由振强
辛艳飞
ZHANG Sheng;YANG Lin;YOU Zhen-qiang;XIN Yan-fei(Center of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China;Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China)
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第9期923-926,共4页
Chinese Journal of Pharmacology and Toxicology
基金
浙江省卫生高层次创新人才培养工程项目~~
关键词
多柔比星
心脏毒性
自噬
doxorubicin
cardiotoxicity
autophagy
作者简介
张升，硕士，助理研究员，主要从事药物毒理学研究，Tel：（0571）87568012，E-mail：zs616568@163．com;通讯作者：由振强，E—mail：youzq1979@163．com，Tel：（0571）87568012;通讯作者：辛艳飞，E-mail：xinyf1976@163．com，Tel：（0571）87568012
