摘要
目的:研究回收式自体输血与异体输血对凝血功能、免疫功能及炎症因子的影响。方法:选择74例患者作为研究对象,并随机分为自体组和异体组,每组各37例。自体组患者接受回收式自体输血;异体组接受异体输血。术后1 d和术后5 d时,测定两组患者的凝血功能指标、免疫功能指标及炎症反应指标。结果:术后1 d和术后5 d时,自体组患者APTT、TT、PT水平及D-D、FDP含量与异体组比较无明显差异;两组患者外周血中CD3+CD4+T细胞、CD3+CD8+T细胞、CD16+CD56+NK细胞的含量均低于手术前,TLR2+细胞、TLR4+细胞的含量以及血清中s CD40L、CINC-1、TNF-α、IL-6的含量均高于手术前且自体组患者外周血中CD3+CD4+T细胞、CD3+CD8+T细胞、CD16+CD56+NK细胞的含量显著高于异体组,外周血中TLR2+细胞、TLR4+细胞的含量以及血清中s CD40L、CINC-1、TNF-α、IL-6的含量显著低于异体组。结论:回收式自体输血在不影响凝血功能的基础上改善免疫功能、抑制炎症反应。
Objective： To study the influence of intraoperative autotransfusion and allogeneic transfusion on coagulation function,immune function and inflammatory factors in patients with cardiac surgery. Methods： 74 patients undergoing cardiac surgery in hospital between June 2014 and February 2017 were selected as the research subjects and randomly divided into two groups,autologous group received intraoperative autotransfusion and allogeneic group received allogeneic transfusion. The blood coagulation function indexes,immune function indexes and inflammatory response indexes of the two groups were measured 1 day and 5 days after surgery. Results： 1 day and 5 days after surgery,APTT,TTnd PT levels as well as D-D and FDP contents of autologous group were not significantly different from those of allogeneic group. 1 day and 5 days after surgery,peripheral blood CD3^＋CD4＋T cell,CD3^＋CD8^＋T cell and CD16^＋CD56^＋NK cell contents were lower than those before surgery,peripheral blood TLR2^＋cell and TLR4＋cell contents as well as serum s CD40 L,CINC-1,TNF-α and IL-6 contents were higher than those before surgery and peripheral blood CD3^＋CD4＋T cell,CD3^＋CD8^＋T cell and CD16^＋CD56^＋NK cell contents were greatly higher than those of allogeneic group,and peripheral blood TLR2^＋cell and TLR4＋cell contents as well as serum s CD40 L,CINC-1,TNF-α and IL-6 contents were greatly lower than those of allogeneic group.Conclusion： Intraoperative autotransfusion for cardiac surgery can improve the immune function and inhibit the inflammatory response without affecting the coagulation function.
作者
屈晶磊
杨远征
QU Jing-lei;YANG Yuan-zheng(Department of Blood Components, Hebei Blood Center, Shijiazhuang 050000,Hebei;Department of Critical Care Medicine, the First Affiliated Hospital of Hainan Medical College, Haikou 570102, Hainan , China)
出处
《川北医学院学报》
CAS
2018年第2期192-195,共4页
Journal of North Sichuan Medical College
基金
海南省卫生计生行业科研项目资助(14A210207)
关键词
回收式自体输血
异体输血
凝血功能
免疫功能
炎症反应
Intraoperative autotransfusion
Allogeneic transfusion
Coagulation function
Immume function
InflammatolT response
作者简介
屈晶磊（1981-），女。E—mail：125026371@qq．com;通讯作者：杨远征，E-mail：hhyangyuanzheng@163．com
