摘要
目的探究高血压肾病早期血尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的变化及临床意义。方法 120例高血压患者作为疾病组,其中40例正常蛋白尿患者作为甲组,40例微量蛋白尿患者作为乙组,40例大量蛋白尿患者作为丙组;120例健康人作为健康组。研究对象均进行NGAL水平检测,并进行组间比较。结果疾病组血NGAL水平(11.63±3.59)μg/L低于健康组的(23.35±7.09)μg/L、尿NGAL水平(3.82±1.21)μg/L高于健康组的(1.60±0.51)μg/L,差异均具有统计学意义(P<0.05)。丙组血NGAL水平低于甲组、乙组、健康组,尿NGAL水平高于甲组、乙组、健康组,差异均具有统计学意义(P<0.05);乙组血NGAL水平低于甲组、健康组,尿NGAL水平高于甲组、健康组,差异均具有统计学意义(P<0.05);甲组血NGAL水平、尿NGAL水平与健康组比较差异均无统计学意义(P>0.05)。结论与健康人群及正常蛋白尿高血压患者相比,高血压肾病早期患者血尿NGAL水平已经出现明显变化,可作为有效诊断标准。
Objective To investigate the change and clinical significance of neutrophil gelatinase-associated lipocalin （NGAL） level in early stage of hypertensive nephropathy. Methods There were 120 hypertension patients as disease group, including 40 cases of normal proteinuria as group A, 40 cases of microalbuminuria as group B, 40 cases of proteinuria as group C. A total of 120 healthy persons as health group. The NGAL level in all subjects were tested and compared between groups. Results Disease group had lower blood NGAL level as （11.63±3.59） μg/L than （23.35±7.09） μg/L in health group, and higher urine NGAL level as （3.82±1.21） μg/L than （1.60±0.51） μg/L in health group. Their difference was statistically significant （P〈0.05）. Group C had lower blood NGAL level than group B, group C and health group, and higher urine NGAL level than group B, group C and health group. Their difference was statistically significant （P〈0.05）. Group B had lower blood NGAL level than group A and health group, and higher urine NGAL level than group A and health group. Their difference was statistically significant （P〈0.05）. Group A had no statistically significant difference in blood NGAL and urine NGAL level, comparing with health group （P〉0.05）. Conclusion Compared with healthy person and hypertensive patients with normal proteinuria, the level of hematuria NGAL in patients with early stage of hypertensive nephropathy has been significantly changed, and it can be used as an effective diagnostic criterion.
作者
侯炜炜
HOU Wei-wei(Department of Clinical Laboratory, Jiangsu Nantong Hospital of Traditional Chinese Medicine Hospital, Nantong 226001, China)
出处
《中国现代药物应用》
2018年第9期18-19,共2页
Chinese Journal of Modern Drug Application
