摘要
提供了一种制备α-乙酰-γ-丁内酯的新方法。在一定条件下,以碳酸钠为催化剂,乙酸乙酯为反应溶媒,γ-丁内酯和乙醛为起始原料,通过乙酰化高压反应,反应液后处理调pH,最后再经过减压精馏得到纯品α-乙酰-γ-丁内酯。探讨了不同催化剂种类、用量、反应时间和pH对反应收率的影响,在最佳反应条件下,α-乙酰-γ-丁内酯的摩尔收率为77.8%。本文提供的新方法原料易得、便宜,操作简易,收率较高,适合工业化生产。
A new method for the preparation of α-acetyl-γ-butyrolactone was studied. Under certain conditions, sodium carbonate was used as catalyst, ethyl acetate was used as reaction solvent,γ-butyrolactone and acetaldehyde were used as raw materials, through the acetylation reaction under high pressure, adjusting pH and reduced pressure distillation, the pure product was obtained. The effect of different kinds and amount of catalyst, reaction time and pH on the yield was investigated. The results showed that, under optimum conditions, the yield of α-acetyl-γ-butyrolactone was 77.8%. This method is simply,and has relatively high yield and low cost. So the method is more suitable for industrial production
作者
皮昌桥
白跃飞
周宏
吴晓璟
刘丹
PI Chang-qiao, BAI Yue-fei, ZHOU Hong, WU Xiao-jing, LIU Dan(Northeast Pharmaceutical Group Co.,Ltd., Liaoning Shenyang 110027, China)
出处
《辽宁化工》
CAS
2018年第3期202-203,206,共3页
Liaoning Chemical Industry
关键词
α-乙酰-γ-丁内酯
合成
碳酸钠
乙醛
α -acetyl-γ-butyrolactone
synthesis
sodium carbonate
acetaldehyde
作者简介
皮昌桥（1985-），男，工程师，辽宁省营口市人，2009年毕业于浙江大学学校制药工程专业，研究方向：药品研发。
