摘要
目的探讨综合康复训练联合盐酸多奈哌齐对阿尔茨海默型病(AD)患者的效果及对事件相关电位的影响。方法将2015年1月~2016年12月收治的112例AD患者随机分为观察组与对照组,每组56例,对照组给予盐酸多奈哌齐治疗,观察组联合综合康复训练,随访3个月,比较两组认知功能、生活质量、事件相关电位。结果观察组蒙特利尔认知评估量表(Mo CA)评分明显高于对照组,身体健康、精力状况、记忆评分明显高于对照组(P<0.05,P<0.01);内源性电位N2、P3潜伏期明显短于对照组,P3波幅明显高于对照组(P<0.05,P<0.01)。结论综合康复训练联合盐酸多奈哌齐有助于改善AD患者认知功能,提高生活质量,可能与调节患者的事件相关电位有关。
Objective To investigate the effect of comprehensive rehabilitation training combined with donepezil on patients with AD and its influence on event-related potential. Method A total of 112 AD patients from January 2015 to December 2016 in our hospital were selected and randomly divided into observation group （ n=56 ） and control group （n=56） . The control group was treated with donepezil hydrochloride, and the observation group was treated with rehabilitation training in extra. After 3 months of follow-up, the cognitive function, living quality and event-related potential in the two groups were compared. Results The score of Montreal cognitive assessment scale （ MoCA ） in observation group was significantly higher than that in control group, and the scores of fitness, energy and memory were significantly higher than those in control group （ P 〈 0.05 ）; the incubation periods of endogenous potentials N2 and P3 were significantly shorter than those in control group, and the amplitude of P3 was significantly higher than that in control group （ P〈0.05 ） . Conclusion Comprehensive rehabilitalion training combined with donepezil can improve the cognitive function and living quality of AD patients, which may be related to the regulation of the event-related potential.
出处
《国际精神病学杂志》
2018年第1期100-102,共3页
Journal Of International Psychiatry
关键词
阿尔茨海默型痴呆
盐酸多奈哌齐
康复训练
事件相关电位
Alzheimer＇s dementia
Donepezil hydrochloride
Comprehensive rehabilitation training
Event related potential
作者简介
张胜利（1974．05-），女，河南洛阳人，本科，主治医师，研究方向：精神卫生。[通讯作者]张胜利（Email：zhangshengli1089@163．com）。
