摘要
目的:探讨初诊急性白血病(acute leukemia,AL)患者血清白蛋白与肾功能的关系及临床意义。方法:收集2015年4月-2017年4月的267例初诊急性白血病患者的临床资料及相关检验结果,进行回顾性横断面分析。采用多元回归模型进行统计分析。结果:初诊AL患者按血清白蛋白四分位分组,血肌酐水平随白蛋白水平的升高而呈降低趋势(第1-4四分位组肌酐的平均水平分别为72.0、65.2、62.8和58.6μmol/L)。多元回归模型分析结果显示,白蛋白每升高1 g/L,血肌酐下降0.89μmol/L。将血清白蛋白以四分位分组进入模型,以第1四分位组为参考组,随着Alb增高,β值呈阶梯下降(第2-第4四分位组β值分别为-12.7,-14.81,-15.98),趋势线检验P<0.05。结论:初诊急性白血病患者血清白蛋白与肌酐水平呈负相关,其升高对肾功能有保护作用。
Objective： To investigate the relationship between serum albumin and renal function in patients with acute leukemia（ AL） and its clinical significance. Methods： The clinical data and related test results of 267 newly diagnosed patients with acute leukemia from April 2015 to April 2017 were collected for retrospective cross-sectional analysis.Multivariate regression model was used for statistical analysis. Results： The creatinine level in serum of newly diagnosed acute leukemia patients decreased with the increase of albumin level（ the first quartile-the fourth quartile had an average creatinine level of 72. 0 μmol/L,65. 2 μmol/L,62. 8 μmol/L,58. 6 μmol/L）; Multiple regression model results showed that each elevated albumin 1 g/L,the serum creatinine level decreased 0. 89 μmol/L. The serum albumin was grouped into the model by quartile,and the first quartile was used as the reference group. With the increase of albunin,the β value decreased steply（ the second and fourth quartile β values were-12. 7,-14. 81,-15. 98）,the trend line test p value was 〈0. 05. Conclusion： Serum albumin negatively correlats with creatinine level in newly diagnosed acute leukemia patients,and its elevation shows protective effect on renal function.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2018年第1期21-25,共5页
Journal of Experimental Hematology
基金
国家自然科学基金(81671584
81670170)
江苏省高校自然科学研究重大项目(16KJA320003)
江苏省青年医学人才(QNRC2016792)
关键词
急性白血病
血清白蛋白
血肌酐
肾功能
acute leukemia
serum albumin
serum creatinine
renal function
作者简介
通讯作者，徐开林，教授．E—mail：lihmd@163．com
