摘要
查阅万方数据库及Pubmed数据库2005至2017年间相关文献,中文关键词为"皮瓣缺血再灌注损伤,信号通路,凋亡,氧化应激,炎症反应,微循环,钙超载",英文关键词为"ischemia and reperfusion of skin flap,signal pathway,apoptosis,oxidative stress,inflammatory reaction,microcirculation,calcium overload",依据纳入排除标准选出35篇。最终选用36篇文献进行分析、总结皮瓣IR过程中相关的细胞信号通路。发现目前与缺血再灌注损伤的信号通路主要有:PI3K/Akt、Nrf2/Keap1-ARE、JAK/STAT、p38 MAPK/IKK/NF-κB、Toll4/NF-κB、PHD-HIF、Trx-1-ASK-MAPK、Trx-MKK4-NF-κB、FOXO-c AMP-PKA-CREB-PGC1α、ROS-ASK1-MKK4/MKK7-JNK、Wnt、c-Jun、PKC-ERKs、HIF-1α/VEGF、Akt/c-myc/VEGF等。可从IR发生、发展的一系列病理生理过程相关的信号转导通路层面出发,预防或减轻皮瓣IR,但IR是一个多因素、多信号调节的病理生理过程,仍存有许多疑问,未来对IR相关细胞信号通路更深入研究将为预防和减轻缺血再灌注提供新的靶点。
Access to the Wanfang database and the Pubmed database for relevant articles published from 2005 to 2017 using the keywords of “ischemia and reperfusion of skin flap,signal pathway,apoptosis,oxidative stress,inflammatory reaction,microcirculation,calcium overload” in Chinese and English, respectively. According to inclusion and exclusion criteria, 35 articles were selected.Finally, 36 articles were selected to analyze and summarize the related cellular signaling pathways during the ischemia-reperfusion injury of the skin flap. We found that, it is believed that the signaling pathways associated with ischemia-reperfusion injury of skin flap are mainly： PI3K/Akt、Nrf2/Keap1-ARE、JAK/STAT、p38 MAPK/IKK/NF-κB、Toll4/NF-κB、PHD-HIF、Trx-1-ASK-MAPK、Trx-MKK4-NF-κB、FOXO-cAMP-PKA-CREB-PGC1α、ROS-ASK1-MKK4/MKK7-JNK、Wnt、c-Jun、PKC-ERKs、HIF-1α/VEGF、Akt/c-myc/VEGF. We can prevent or mitigate the ischemia-reperfusion injury of fap from the level of signal transduction pathway related to a series of pathophysiological processes that occur and develop in IR. IR is a pathophysiological process which afected by many factors and involved a variety of molecular mechanisms regulation, but there are still some questions. Further research on IR related cell signaling pathway will provide new targets for prevention and reduction of ischemia reperfusion injury of skin fap.
出处
《中国医疗美容》
2018年第1期92-97,共6页
China Medical Cosmetology
关键词
皮瓣
缺血再灌注损伤
细胞信号通路
Flap
Ischemia-reperfusion injury
Cell signaling pathway
