摘要
目的:研究新辅助化疗不同给药途径对宫颈癌组织中癌细胞生长信号通路功能的影响。方法:选择2008年7月~2016年7月期间在扶风县人民医院接受新辅助化疗的宫颈癌患者作为研究对象,随机分为介入组和静脉组,分别接受新辅助介入动脉化疗以及新辅助静脉化疗。手术切除后,测定宫颈癌病灶内PI3K/AKT/mTOR、Wnt/β-catenin、MEK/ERK信号通路分子的含量。结果:介入组患者宫颈癌病灶内p-PI3K、p-AKT、mTOR、MMP2、VEGFβ-catenin、CyclinD1、Twist、Slug、Snail、MEK1、MEK2、ERK1/2、Bcl-2的蛋白含量均显著低于静脉组,E-cadherin、Bax的蛋白含量均显著高于静脉组,差异均有统计学意义(P<0.05)。结论:新辅助介入动脉化疗能够较新辅助静脉化疗更为有效地抑制宫颈癌病灶内PI3K/AKT/mTOR、Wnt/β-catenin、MEK/ERK信号通路所介导的癌细胞生长。
Objective:To study the effects of different administration routes of neoadjuvant chemotherapy on cancer cell growth signal pathway function in cervical cancer.Methods:Patients with cervical cancer who received neoadjuvant chemotherapy in Fufeng People's Hospital between July 2008 and July 2016 were selected as the research subjects and randomly divided into intervention group and intravenous group who accepted the neoadjuvant interventional arterial chemotherapy and neoadjuvant intravenous chemotherapy respectively.After surgical resection,the contents of PI3 K/AKT/mTOR, Wnt/β-catenin and MEK/ERK signaling pathway in cervical cancer lesions were determined.Results:p-PI3 K,p-AKT,mTOR,MMP2,VEGF,β-catenin,CyclinD1,Twist,Slug,Snail,MEK1,MEK2,ERK1/2 and Bcl-2 protein levels in cervical cancer lesion of intervention group were significantly lower than those of intravenous group whereas E-cadherin and Bax protein levels were significantly higher than those of intravenous group.Conclusion:Neoadjuvant interventional arterial chemotherapy can be more effective than neoadjuvant intravenous chemotherapy to inhibit the cancer cell growth mediated by PI3 K/AKT/mTOR,Wnt/β-catenin and MEK/ERK signaling pathway in cervical cancer.
出处
《海南医学院学报》
CAS
2018年第2期216-219,共4页
Journal of Hainan Medical University
基金
陕西省科学技术研究发展计划项目(2009k12-01)~~
关键词
宫颈癌
新辅助化疗
介入动脉化疗
信号通路
Cervical cancer
Neoadjuvant chemotherapy
Interventional arterial chemotherapy
Signaling pathway
作者简介
白煜（1971-）,女,陕西扶风县人,副主任医师,学士,E-mailqweyuirt＠163.com.
