摘要
随着先心病手术早期病死率和并发症率显著降低,术后长远期并发症、特别是神经系统并发症越来越受到关注.以往人们认为先心病手术后神经损伤主要是由于心脏手术中体外循环所致,然而随着手术和体外循环技术提高,体外循环脑损伤发生率已经明显降低,多年来试图通过改进体外循环灌注方法来降低神经系统损伤的效果已并不明显.近年发现在胎儿期及术前先心病患儿即存在脑发育延迟和损伤,并证实这种脑发育异常可能比手术中体外环循环脑损伤对患儿长远期神经发育的影响更为重要,因此加强先心病胎儿期及术前脑发育异常的认识具有重要临床意义.本文就这一研究领域研究现状和进展作一综述.
While the early mortality and complication rate of the congenital heart disease were significantly reduced, the long-term complications, especially the neurological complications, have become more and more concerning. Periopeartive nerve injury was used to be mainly attributed to cardiopulmonary bypass, however, with improvement of surgical and cardiopulmonary bypass technology, this has become significantly lower. For many years efforts to reduce nervous system damage by improving the cardiopulmonary bypass perfusion method has yielded little results. In recent years, it is found that during preoperative period, even as early as fetal period, children with congenital heart disease show slow brain development and damage, which was considered to be more important than extracorporeal circulation in determining long-term nervous system development. Thus recognition of preoperative brain malfunction in children with congenital heart disease has important clinical significance. This paper reviews the recentresearch and progress in this area.
出处
《中华胸心血管外科杂志》
CSCD
2017年第12期760-763,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
作者简介
通信作者：祝忠群Email：zzgheart@aliyun．com
