摘要
目的:探讨硫辛酸联合苦碟子治疗糖尿病周围神经病变的有效性与安全性。方法:选取166例糖尿病周围神经病变患者,随机分为观察组与对照组,各83例,观察组采用硫辛酸联合苦碟子治疗,对照组采用单一硫辛酸治疗,比较两组治疗效果、疼痛强度简易量表(Verbalratingscale,VRS)评分及不安全事件发生率等。结果:观察组的治疗总有效率为96.4%(80/83),高于对照组的88.0%(73/83)(P<0.05);治疗后观察组VRS得分为(2.05±0.16)分,低于对照组患者[(2.89±0.20)分](P<0.05);观察组不安全事件发生率为2.4%(2/83),对照组为3.6%(3/83),两组比较差异无统计学意义(P>0.05)。结论:硫辛酸与苦碟子治疗糖尿病周围神经病变治疗效果较好,可降低患者的疼痛强度,安全性也较高。
Objective ：To evaluate the efficacy and safety of lipoic acid combined with Kudiezi in the treatment of diabetic peripheral neuropathy. Methotls：166 eases of diabetic peripheral neuropathy patients in our hospital were selected and divided into observation group and control group according to random number table, 83 cases in each group. The observation group was treated with lipoic acid combined with Kudiezi, and the control group was treated with lipoie acid. The efficacy, VRS score and incidence of unsafe events were compared between the two groups. Re- stilts：The overall effective rate in the observation group was 96.4 % （80/83）, which was higher than that in the control group （88 %, 73/83 ） （ P 〈 0.05 ）. After treatment, the average VRS score in the observation group was 2.05 ± 0.16 （points）, the average VRS score in the control group was 2.89 ± 0.20 （points） , and the difference was statistically significant （ P 〈 0.05 ）. The incidence of unsafe events in the observation group was 2.4 % （2/83） and in the control group was 3.6 % （ 3/83 ）, and the difference was not statistically significant （ P 〉 0.05 ）. Conclusion：The efficacy of lipoic acid combined with Kudiezi in the treatment of diabetic peripheral neuropathy is better. It can reduce the patient＇s pain intensity, with a certain security.
出处
《包头医学院学报》
CAS
2017年第11期56-57,共2页
Journal of Baotou Medical College
