摘要
目的探讨丁苯酞软胶囊联合阿托伐他汀钙片对脑梗死患者神经功能恢复及日常生活能力的影响。方法选取脑梗死患者68例，按数字表法随机分为对照组和研究组，每组34例。对照组采用常规治疗措施，研究组在对照组用药基础上加用阿托伐他汀钙片及丁苯酞软胶囊，两组均持续治疗3个月。统计对比两组入院时及疗程结束后神经功能评分（NIHSS）、日常生活能力评分（ADL）及实验室指标[同型半胱氨酸（Hey）、血管紧张素Ⅱ（ANGII）、神经元特异性烯醇化酶（NSE）]水平变化情况、临床疗效、不良反应发生率。结果治疗前研究组NIHSS评分及ADL评分与对照组比较，差异未见统计学意义（P〉0．05）；治疗后研究组NIHSS评分及ADL评分低于对照组，差异有统计学意义（P〈0．05）。研究组治疗有效率91．18％（31／34）高于对照组67．65％（23／34），差异有统计学意义（P〈0．05）。治疗前研究组血清Hcy、ANGII、NSE水平与对照组比较，差异未见统计学意义（P〉0．05），治疗后研究组各指标水平低于对照组，差异有统计学意义（P〈0．05）。研究组不良反应发生率[11．76％（4／34）]与对照组[8．82％（3／34）]比较差异未见统计学意义（P〉0．05）。结论联合应用阿托伐他汀钙片及丁苯酞软胶囊治疗脑梗死效果显著，可有效改善患者神经功能及日常生活能力，提高治疗效果，且安全性较高。
Objective To investigate the effects of butyphthalide soft capsule combined with atorvastatin calcium on neurological function recovery and activity of daily living of patients with cerebral infarction. Methods Sixty-eight patients with cerebral infarction were divided into control group （n = 34） and study group （n = 34） according to random number table method. The control group was treated by conventional measures, the study group, on the basis of treatment in control group, was treated with bu- typhthalide soft capsule and atorvastatin calcium, both groups were treated for 3 months. Neurological function score （NIHSS）, activity of daily living score （ADL） and laboratory indexes [ homocysteine （ Hcy）, angiotensin Ⅱ （ ANG Ⅱ） , neuron specificity enolase （NSE） ] levels, clinical efficacy and the incidence of adverse reactions were statistically compared between the two groups at admission and after treatment. Results The NIHSS and ADL score of study group were not significantly different from those of control group before treatment （P 〉 0. 05 ）, but after treatment, the NIHSS and ADL score of study group were significantly lower than those of control group （ P 〈 0.05 ）. The positive rate in study group [91.18% （31/34） ] was significantly higher than that in control group [67.65% （23/34） ], P 〈0.05. The levels of serum Hcy, ANG l] and NSE in study group were not significantly different from those in control group （ P 〉 0.05 ） ; but after treatment, the levels in study group were significantly lower than those in control group （ P 〈 0. 05 ）. There was no significant difference in the incidence of adverse events between study group [ 11.76% （4/34）] and control group [8.82% （3/34）], P 〉 0.05.Conclusions Butyphthalide soft capsule combined with atorvastatin calcium gets significant effect in treatment of cerebral infarction, which can improve neurological function, activity of daily living of pa- tients, and the therapeutic effect with high safety.
出处
《中国实用医刊》
2017年第23期116-119,共4页
Chinese Journal of Practical Medicine
关键词
丁苯酞软胶囊
阿托伐他汀钙片
脑梗死
神经功能
日常生活能力
Butylphthalide soft capsules
Atorvastatin calcium tablets
Cerebral infarction
Neu- rological function
Daily living ability
作者简介
通信作者：于广周，Email：cvxcpo@126．com
