摘要
目的:探究不同剂量阿托伐他汀治疗老年急性冠脉综合征(acute coronary syndrome,ACS)患者的临床疗效。方法:撷取河南大学第一附属医院收治的老年急性冠脉综合征患者95例,撷取时间是自2015年4月至2017年4月,分观察组(n=47)和对照组(n=48)。对照组予以20mg阿托伐他汀治疗,观察组予以40mg阿托伐他汀治疗。比较血脂指标、肝功能、血管炎性指标、不良反应。结果:与对照组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)指标比较,观察组较低;与对照组HDL-C指标比较,观察组较高;与对照组AST、ALT指标比较,观察组较高;与对照组IL-6、hs-CRP指标比较,观察组的较低,具统计学差异,P<0.05;与对照组不良反应发生率比较,观察组差异不突出,P>0.05。结论:40mg的阿托伐他汀可有效缓解老年急性冠脉综合征患者的病情,改善肾功能,值得借鉴。
Objective： To explore the effects of different doses of atorvastatin in the treatment of elderly acute coronary syndrome. Methods： 95 cases of elderly Patients with acute coronary artery syndrome in our hospital from April 2015 to April 2017 were divided into observation group（n=47）and control group（n=48）. The control group was treated with 20 mg atorvastatin, observation group was treated with 40 mg atorvastatin. Blood lipids,liver function, adverse reaction vasculitis index were studied. Results： Compared with the control group, LDL-C, TC, TG and HDL-C was lower in the observation group; Index was higher in the observation group; AST, ALT was higher in the observation group; IL-6, hs-CRP in the observation group was lower, with statistically significant difference, P〈0.05; and the incidence of adverse reactions in the observation group showed no difference,P〉0.05. Conclusion： 40 mg atorvastatin can effectively alleviate the acute coronary syndrome in the elderly patients, thus it is worthy of reference.
出处
《药品评价》
CAS
2017年第23期5-7,共3页
Drug Evaluation
基金
河南省科技发展计划项目(110329)
作者简介
寇威,女,硕士,心血管专业临床药师,主要从事心血管药物的研究.电话：0371-22736862;E-mail：157921839@qq.com;通讯作者：宋志明,男,博士,主要从事细胞衰老与动脉硬化关系的研究.电话：0371-22731372;E-mail：songzhim@vip.henu.edu.cn
