摘要
目的:研究不同核苷类似物对慢性乙肝患者肝纤维化及外周血树突状细胞(dendritic cell,DC)功能的影响。方法:选择2014年4月~2016年10月期间在黄浦区传染病医院接受抗病毒治疗的慢性乙型肝炎患者作为研究对象,分为3组,A组患者接受恩替卡韦治疗、B组接受阿德福韦酯治疗、C组接受拉米夫定治疗。治疗后24周、48周后,分别测定三组患者血清中肝纤维化指标、外周血中DC含量及表面标志分子的表达量。结果:治疗后,各组患者血清中透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、层黏连蛋白(LN)、Ⅳ型胶原(C-Ⅳ)的含量显著低于治疗前,外周血中髓样DC(mDC)、浆细胞样DC(pDC)的数目以及外周血DC表面分子CD80、CD86、CD1α、HLA-DR的表达量显著高于治疗前。治疗后A组患者血清中HA、PC-Ⅲ、LN、C-Ⅳ的含量显著低于B、C组,外周血中mDC、pDC的数目以及外周血中DC表面分子CD80、CD86、CD1α、HLA-DR的表达量显著高于B、C组。结论:核苷类似物抗病毒治疗能有效抑制慢乙肝患者肝纤维化,改善外周血DC功能,恩替卡韦作用尤为明显。
Objective:To study the effect of different nucleoside analogues on liver fibrosis and peripheral blood dendritic cell function of patients with chronic hepatitis B.Methods:Patients with chronic hepatitis B who received antiviral therapy in Infectious Diseases Hospital of Shanghai Huangpu District between April 2014 and October 2016 were selected as the research subjects and divided into 3 groups,group A received entecavir therapy,group B received adefovir dipivoxil therapy and group C received lamivudine therapy.24 weeks and 48 weeks after treatment,the levels of liver fibrosis indexes in serum as well the levels of DC and the expression of surface markers in peripheral blood of the three groups were measured respectively.Results:After treatment,serum hyaluronic acid(HA),procollagen Ⅲ(PC-Ⅲ),laminin(LN)and collagen type Ⅳ(C-Ⅳ)levels of all groups were significantly lower than those before treatment,and the number of myeloid DC(mDC)and plasmacytoid DC(pDC)in peripheral blood as well as the expression levels of DC surface molecules CD80,CD86,CD1αand HLA-DR in peripheral blood were significantly higher than those before treatment.After treatment,the serum levels of HA,PC-Ⅲ,LN and C-Ⅳ in group A were significantly lower than those in group B and C,and the number of mDC and pDC in peripheral blood as well as the expression of DC surface molecules CD80,CD86,CD1α and HLA-DR in peripheral blood were significantly higher than those in group B and C.Conclusion:Antiviral therapy by nucleoside analogues can effectively inhibit liver fibrosis and improve peripheral blood DC function in patients with chronic hepatitis B,and Entecavir function is better than that of adefovir dipivoxil and lamivudine.
出处
《海南医学院学报》
CAS
2017年第23期3219-3222,共4页
Journal of Hainan Medical University
基金
上海市黄浦区卫计委科技项目(HKW201551)~~
作者简介
冯晓霞（1983-）,女,山东人,硕士,主治医师,E-mail：2848721383＠qq.com.
