摘要
目的:探讨子宫内膜良恶性病变的超声造影参数测定及其与恶性分子表达的相关性。方法:收集2012年12月~2017年1月间在本院检查并诊断的子宫内膜良性增生患者118例作为子宫内膜增生组,子宫内膜癌患者67例作为子宫内膜癌组。对比两组患者的子宫超声造影参数水平,子宫内膜病灶组织增殖、凋亡、侵袭基因表达量的差异。采用Pearson检验评估子宫超声造影参数与病灶组织恶性分子表达量的相关关系。结果:子宫内膜癌组的超声造影参数TTP水平低于子宫内膜增生组,PI水平高于子宫内膜增生组。子宫内膜癌组病灶组织中增殖基因EFEMP2mRNA的表达量低于子宫内膜增生组,RRM2、DJ-1mRNA的表达量高于子宫内膜增生组;凋亡基因P53、c-myc、Livin mRNA的表达量高于子宫内膜增生组,Caspase-3、Bid mRNA的表达量低于子宫内膜增生组;侵袭基因DKK1mRNA的表达量低于子宫内膜增生组,HMGB1、EZH2、Snail mRNA的表达量高于子宫内膜增生组。经Pearson检验发现,子宫内膜癌超声造影参数水平与病灶组织中恶性分子表达量直接相关。结论:超声造影参数水平可用于鉴别子宫内膜良恶性病变,且与病变严重程度直接相关。
Objective:To measure the contrast-enhanced ultrasound parameters of endometrial benign and malignant lesions and investigate their correlation with malignant molecule expression.Methods:118 patients who were examined and diagnosed with endometrial benign hyperplasia in the hospital between December 2012 and January 2017 were collected as endometrial hyperplasia group,and 67 patients with endometrial carcinoma were collected as endometrial cancer group.The differences in the levels of uterine contrast-enhanced ultrasound parameters as well as the expression of proliferation,apoptosis and invasion genes in endometrial lesion tissue were compared between the two groups.Pearson test was used to evaluate the correlation between uterine contrast-enhanced ultrasound parameters and malignant molecule expression in the lesions.Results:Contrastenhanced ultrasound parameter TTP level of endometrial cancer group was lower than that of endometrial hyperplasia group whereas PI level was higher than that of endometrial hyperplasia group.Proliferation gene EFEMP2 mRNA expression in lesion tissue of endometrial cancer group was lower than that of endometrial hyperplasia group whereas RRM2 and DJ-1 mRNA expression were higher than those of endometrial hyperplasia group;apoptosis genes P53,c-myc and Livin mRNA expression were higher than those of endometrial hyperplasia group whereas Caspase-3 and Bid mRNA expression were lower than those of endometrial hyperplasia group;invasion gene DKK1 mRNA expression was lower than that of endometrial hyperplasia group whereas HMGB1,EZH2 and Snail mRNA expression were higher than those of endometrial hyperplasia group.Pearson test showed that the contrast-enhanced ultrasound parameter levels of endometrial cancer were directly correlated with the malignant molecule expression in the lesion tissues.Conclusion:contrast-enhanced ultrasound parameter levels can be used to identify endometrial benign and malignant lesions and are directly correlated with the severity of the lesion.
出处
《海南医学院学报》
CAS
2017年第22期3116-3119,3123,共5页
Journal of Hainan Medical University
基金
2015湖北省卫计委重点项目(WJ2015MA122)~~
关键词
子宫内膜病变
超声造影
增殖基因
凋亡基因
侵袭基因
Endometrial lesion
Contrast-enhanced ultrasound
Proliferation gene
Apoptosis gene
Invasion gene
作者简介
刘支义（1976-）,男,湖北恩施人,本科,主治医师,E-mail：liuzhiyi1221@163.com.;[通讯作者]胡亚飞,E-mail：huyafeiwin@163.com.
