摘要
目的探讨牙种植体周围龈沟液中可溶性髓样细胞触发性受体-1(soluble triggering receptor expressed on myeloid cell,sTREM-1)的水平与种植体周围炎的关系。方法收集2013年1月—2016年12月在莆田学院附属医院行牙种植术后出现不同程度牙种植体周围炎的46名患者(种植体75颗)为研究对象,选取同期来院行牙种植术后种植体周围组织健康的患者18名(种植体25颗)为对照组。收集种植体周围龈沟液,采用ELISA法检测龈沟液样本中sTREM-1的浓度,记录种植体周围袋深度(peri-implantitis peroxidase depth,PPD)、种植体周牙槽骨丧失深度(The distance from the shoulder of the implant to the bottom of the bony defect,DSB)、改良龈沟出血指数(modified sulcus bleeding index,m SBI)和改良菌斑指数(modified plaque index,m PLI);分析种植体周围PPD、DSB、mSBI、mPLI和sTREM-1的相关性。结果轻度、中度、重度种植体周围炎龈沟液中sTREM-1的浓度均高于健康组(P<0.05);重度种植体周围炎龈沟液中sTREM-1的浓度高于轻度和中度种植体周围炎组(P<0.05);轻度和中度种植体周围炎龈沟液中sTREM-1的浓度差异无统计学意见(P>0.05)。sTREM-1的浓度与植体周围PPD、DSB、mSBI、mPLI均呈正相关。结论种植体周围炎龈沟液中sTREM-1的浓度与种植体周围组织的炎症程度密切相关,随着组织炎症严重程度的增加而升高。
Objective To investigate the relationship between the level of the soluble triggering receptor expressed on myeloid cell（sTREM-1） in the gingival crevicular fluid（GCF） of individuals and peri-implantitis. Methods 46 patients（75 implants） with different severities of peri-implantitis and 18 patients（75 implants） without peri-implantitis were selected in this study. The concentrations of sTREM-1 in GCF with different types of peri-implantitis were detected by enzyme-linked immunosorbent assay（ELISA）. The peri-implantitis peroxidase depth（PPD）, the distance from the shoulder of the implant to the bottom of the bony defect（DSB）, the modified sulcus bleeding index（m SBI） and the modified plaque index（m PLI） were recorded. The correlation between PPD, DSB, m SBI, m PLI and sTREM-1 was analyzed.Results The concentrations of sTREM-1 in GCF in mild, moderate and severe peri-implantitis group were significantly higher than those in healthy group（P〈0.05）. The concentrations of sTREM-1 in GCF in severe peri-implantitis group were significantly higher than those in mild and moderate group（P〈0.05）. There was no significant difference in the concentration of sTREM-1 in GCF between mild peri-implantitis group and moderate group（P〉0.05）. In addition, there was a significant positive correlation between the concentration of sTREM-1 and PPD, DSB, mSBI,mPLI. Conclusions The concentration of sTREM-1 in GCF is closely related to the severity of tissue inflammation around implant.
出处
《口腔疾病防治》
2017年第12期784-787,共4页
Journal of Prevention and Treatment for Stomatological Diseases
基金
福建省医学创新课题基金资助项目(2015-CX-30)
莆田学院科研基金项目(2016050)
作者简介
郑德春,副主任医师,硕士,Email：ptchung@163.com;【通信作者】吴东,主任医师,硕士,Email：wudong510_5@hotmail.com
