摘要
目的了解广东省不同胎龄新生儿胆红素脑病发病状况。方法设计问卷调查表，采用分层随机抽样调查法随机选取广东省设有新生儿科的二甲以上医院21家，以2014年间在人选医院新生儿科住院且出院诊断为胆红素脑病的患儿为研究对象，记录患儿临床资料。结果2014年间广东省地区共159例患儿诊断为胆红素脑病，其中出生胎龄〈34周8例，占5．03％；34周≤出生胎龄〈37周30例，占18．87％；37周≤出生胎龄〈42周119例，占74．84％；出生胎龄≥42周2例，占1．26％。胆红素脑病的常见三大病因中，葡萄糖-6-磷酸脱氢酶（G6PD）缺陷70例，同族免疫性溶血47例，新生儿感染67例，但不同胎龄间常见病因的发生比例比较差异无统计学意义（P〉0．05）。部分胆红素患儿存在两种或更多种病因，但不同胎龄间是否存在多种病因的差异无统计学意义（P〉0．05）。结论广东省胆红素脑病患儿中，不同胎龄间胆红素脑病的病因构成相同，且均以葡萄糖-6-磷酸脱氢酶缺陷、同族免疫性溶血和新生儿感染为最常见。
Objective To analyze the clinical characteristics of bilirubin encephalopathy in neonates at different gestational age in Guangdong Province. Methods Designed a questionnaire, selected 21 grade 2 A and above hospitals with neonatal department in Guangdong Province with the stratified random sampling method, with neonates diagnosed as bilirubin encephalopathy from neonatal department of 21 hospitals in 2014 as the object of study, recorded their clinical data. Results In 2014, 159 cases of bilirubin encephalopathy were reported from 21 hospitals; there were 8 cases of 〈34 weeks＇ gestational age （5.03%）, 30 cases of 34-37 weeks＇ gestational age （18.87%）, 119 cases of 37-42 weeks＇ gestational age （74,84%）, 2 cases of ≥ 42 weeks＇ gestational age （1.26%）. Most of the cases were caused by G-6PD deficiency （70 cases）, hemolytic disease of the newborn （47 cases）, and neonatal infection （67 cases）; but there was no statistically significant difference in the rates of common causes among different gestational age （P〉0.05）. Some of the cases were caused by two or more kinds of diseases, but there was no statistically significant difference in the rate of multiple causes among different gestational age （≥0.05）. Conelusions Most of the infants with bilirubin encephalopathy in the survey were caused by G-6PD deficiency, hemolytic disease of the newborn, and neonatal infection, but the etiology of bilirubin encephalopathy in the cases were the same even in different gestational ages.
出处
《国际医药卫生导报》
2017年第24期3826-3828,共3页
International Medicine and Health Guidance News
基金
广东省科技计划项目（2014A020212589）
关键词
胎龄
胆红素脑病
流行病学
病因
Gestational age
Bilirubin encephalopathy
Epidemiology
Etiology
作者简介
通信作者：陈运彬，E—mail：yunbin_chen@hotmail．com
