摘要
目的通过对稽留流产患者的流产绒毛组织进行染色体核型分析,探讨染色体异常与稽留流产之间的关系。方法对2011年2月至2017年6月,因稽留流产在我院行流产绒毛组织培养和染色体核型分析的286例患者进行回顾性分析。结果 286例稽留流产绒毛组织中,培养成功262例,成功率为91.61%(262/286)。共检出异常核型135例,异常率为51.53%(135/262),其中数目异常占118例(87.41%,118/135),结构异常17例(12.59%,17/135)。结论胚胎染色体异常,尤其数目异常是导致孕妇稽留流产的最主要原因,为流产孕妇提供绒毛组织染色体核型分析可明确其稽留流产原因,对再发风险评估提供科学的理论依据。
Objective：To explore the relationships between chromosomal abnormalities and spontaneous abortion via chromosomal karyotyping on embryos of miscarried pregnants. Methods：Reviewed and analyzed 286 cases of abortion villi which were conducted cell culture and karyotyping. Results：262（91.61%,262/286）cases were successfully cultured and karyotyped over all 286 samples. Which of 135（51.53%,135/262）cases were detected chromosomal abnormalities,118（87.41%,118/135）cases were numerical abnormalities,17（12.59%,17/135）cases were structural abnormalities,respectively. Conclusion：Fetal chromosomal abnormality is playing an important role in spontaneous abortion. Chromosomal analysis of chorionic villi tissues can provide reference for further gestation.
出处
《中国优生与遗传杂志》
2017年第11期77-78,25,共3页
Chinese Journal of Birth Health & Heredity
基金
深圳市龙岗区科技计划项目(YLWS20150610155602039)
关键词
自然流产
绒毛
细胞培养
染色体异常
Spontaneous Abortion
Chorionic Villi~ Cell Culture
Chromosomal Abnormalities
