摘要
目的:建立用LC-MS/MS测定抗氧剂1076的含量测定方法。方法:采用Eclipse Plus C_8(2.1 mm×50 mm,1.8μm)色谱柱;流动相:0.1%甲酸-甲醇(2∶98);柱温:35℃;离子源:A-PCI源。结果:抗氧剂1076在0.269~21.52μg·m L^(-1)范围内线性关系良好,相关系数为0.999 3,平均回收率为95.5%,RSD为3.5%,检出限为0.001μg·m L^(-1)。结论:该方法灵敏度高,检出限低,可用于药品中抗氧剂1076的迁移量测定。
Objective： To establish a method for the determination of the content of antioxidant 1076 by the LC-MS/MS. Methods： Using ZORBAX Eclipse Plus Cs column （ 2. 1 mm ×50 mm, 1.8 μm ） ; Mobile phase ： The 0. 1% formic acid and methanol was 2：98; Column temperature was 35 ℃; Ion source： A-PCI source. Results： The linearity was good between 0. 269 μg· mL-1-21.52 μg·mL-1. The correlation coefficient was 0. 999 3. The average recovery rate was 95.5%, RSD was 3.5% and the detection limit was 0. 001 μg. mL-1. Conclusion： This method has high sensitivity and low detection limit, thus can be used for the determination of migration quantity of antioxidant 1076 from medicine packaging migration to drugs.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2017年第11期2101-2105,共5页
Chinese Journal of Pharmaceutical Analysis
作者简介
Tel：（028）64020272；E-mail：xzylxl@126．com
