摘要
目的考察醒脑静注射液(麝香、栀子、郁金、冰片)联合高压氧对急性一氧化碳(CO)中毒患者治疗效果。方法选择2013年1月—2016年1月间于我院急诊科收治的74例急性CO中毒患者,随机分为两组,对照组予高压氧治疗,观察组予高压氧联合醒脑静注射液治疗,比较两组临床疗效及其对血清C反应蛋白(CRP)、谷丙转氨酶(ALT)、血肌酐(Scr)水平的影响。结果观察组患者苏醒时间、住院时间明显短于对照组,迟发性脑病发生率明显低于对照组,有效率明显高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者血清MDA、CRP及ALT、Scr均较治疗前显著下降,SOD明显上升,且观察组明显优于对照组,差异均有统计学意义(P<0.05)。结论醒脑静注射液联合高压氧治疗急性CO中毒时,可清除氧自由基,抑制炎症反应,改善临床症状,减少迟发性脑病发生,保护肝肾功能,进而改善临床疗效。
AIM To investigate the therapeutic effects of Xingnaojing Injection（Moschus,Gardeniae Fructus,Curcumae Radix,Borneolum Syntheticum） combined with hyperbaric oxygen on patients with acute carbon monoxide（CO） poisoning. METHODS Seventy-four cases of patients with acute CO poisoning treated from Jan 2013 to Jan 2016 in emergency department of our hospital were selected and randomly assigned into two groups. Control group was treated with hyperbaric oxygen,and observation group was treated with hyperbaric oxygen combined with Xingnaojing Injection. Clinical curative effects and the effects on levels of serum C-reactive protein（CRP）,alanine aminotransferase（ALT）,serum creatinine（Scr） between the two groups were compared. RESULTS Recovery time and hospitalization time in the observation group were significantly shorter,delayed encephalopathy rate was significantly lower,and efficacy rate was significantly higher than those in the control group,all the differences were statistically significant（P 〈 0. 05）. After the treatment,serum MDA,CRP,ALT and Scr in the two groups were significantly decreased,and SOD was significantly increased as compared with those before the treatment. These indices in the observation group were significantly better than those in the control group,all the differences were statistically significant（P 〈 0. 05）. CONCLUSION Xingnaojing Injection combined with hyperbaric oxygen can scavenge oxygen free radicals,inhibit inflammatory reaction,improve clinical symptoms,reduce delayed encephalopathy occurance,protect liver and kidney function and then improve clinical efficacy in the treatment of acute CO poisoning.
出处
《中成药》
CAS
CSCD
北大核心
2017年第11期2269-2272,共4页
Chinese Traditional Patent Medicine
基金
广东省自然科学基金博士启动项目(10451008901004959)
关键词
醒脑静注射液
急性CO中毒
高压氧
Xingnaojing Injection
acute carbon monoxide poisoning
hyperbaric oxygen
作者简介
田应海（1968～），男，硕士，副主任医师，从事急诊、ICU专业工作。Tel：13632491539，E-mail：tyhai-719@163．com
