摘要
目的:探讨新生儿ABO溶血症(ABO-HDN)与O型血母亲抗体效价的相关性。方法:选择712例O型血母亲所产新生儿,对血型为A型、B型的新生儿做ABO-HDN检测,并取其母亲的静脉血进行抗A/B免疫球蛋白G(IgG)效价检测,分析母亲抗IgG效价与ABO-HDN发生率的关系。结果:本组新生儿共检出111例ABO-HDN阳性患儿,ABO-HDN发生率为15.59%(111/712)。ABO-HDN发生率与母亲抗体IgG效价呈正相关(r=0.96,P<0.01);ABO-HDN患儿黄疸出现时间与母亲抗IgG效价无显著相关性(P>0.05)。母亲抗IgG效价≤1∶64组溶血新生儿达到光疗指征率、1周内贫血发生率及换血率均低于其他两组(P<0.05);母亲抗IgG效价≥1∶256组溶血新生儿1周内贫血发生率及换血率高于母亲抗IgG效价1∶128组(P<0.05)。结论:对O型血母亲所产A型或B型血新生儿,早期行溶血三项及抗体效价检查,可预估新生儿发生溶血的可能性及严重程度。
Objective： To investigate the correlation between the newborn with ABO hemolytic disease（ ABO-HDN） and the antibody titer of the mother with type O blood. Methods： Seven hundreds and twelve cases of type O blood mothers of newborns were selected as a research object,the ABO-HDN of newborns with type A blood and type B blood were tested,and the mother’s blood were taken for anti-A/B immunoglobulin G（ IgG） titer detection,relationship between maternal anti IgG titer and the incidence of ABO-HDN were analyzed. Results： A total of 111 neonates with ABO-HDN positive were detected in this group,and the incidence of ABO-HDN was 15. 59%（ 111/712）. The incidence of ABO-HDN was positively correlated with the titer of maternal antibody IgG（ r = 0. 96,P〈0. 01）.There was no significant correlation between the time of jaundice and the anti IgG titer of ABO-HDN in children（ P 〉 0. 05）. The indications of phototherapy,the incidence of anemia in neonates within 1 week and exchange transfusion rate of mother anti-titers ≤1 ∶ 64 group were all lower than those in the other two groups（ P 〈 0. 05）. The incidence of anemia in neonates within 1 week and exchange transfusion rate of mother anti-titers ≥1 ∶ 256 group were significantly higher than those in the mother anti-titers = 1 ∶ 128 group（ P〈0. 05）. Conclusion： For the blood type A or B blood newborns of type O blood mothers,the early detection of three items of hemolysis and antibody titer can predict the possibility and severity of hemolytic disease in newborns.
作者
李雪瑞
付琳
马正民
宋少峰
Li Xuerui Fu Lin Ma Zhengmin(Song Shaofeng,North Hospital of Xi’a)
出处
《儿科药学杂志》
CAS
2017年第11期8-10,共3页
Journal of Pediatric Pharmacy
关键词
ABO溶血症
O型血
抗体效价
ABO hemolytic disease
type O blood
antibody titer
作者简介
李雪瑞（1970．03～），女，大学本科，副主任医师，主要从事新生儿疾病临床工作，E—mail：lixr2136@sina．com。
