摘要
大鼠脑内单侧黑质注射6羟基多巴胺(6OHDA)后,受损侧纹状体DA及其代谢物二羟苯乙酸和高香草酸含量分别下降88.4%,81.0%和60.1%。5HT与对侧相比略有增加(+13%),5羟吲哚醋酸无显著差异,提示6OHDA选择性地损毁了单侧黑质—纹状体DA神经通路。皮下注射阿朴吗啡(APO)后能诱发损伤大鼠向健侧方向旋转。阿朴啡类生物碱(1-STP)(10mg/kg)能拮抗APO的上述旋转作用,增大剂量(15mg/kg)作用增强,呈剂量—效应依赖关系。结果提示1-STP具有突触后DA受体阻滞作用。
Rats receiving unilateral nigral injection of 6 OHDA resulted in distinct reduction of DA (-88% ) , DOPAC(-80%) and HVA(-60%) in striatum of lesioned side, and the contents of 5HT and 5HIAA remained almost constant in comparison with that of contralateral striatum, suggesting selective lesion of nigrostriatal dopaminer-gic pathway induced by 6OHDA. Following 6OHDA lesion the rats exhibited circling behaviour after APO challenge. 1-Stephaniae ( 1-STP ) significantly antagonizied the action of APO in circling model in dose-dependent manner. Our results indicate that 1-STP possesses the ability to block DA receptor of central nervous system.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期19-22,共4页
Chinese Pharmacological Bulletin
基金
中国科学院科学基金资助课题
关键词
千金藤碱
旋转模型
L-stephanine
Circling model
DA receptor blocker
