摘要
目的:了解不同部位及不同病原体感染所引起的脓毒症患者血清降钙素原(PCT)和D-二聚体水平。方法:收集116例脓毒血症患者的临床资料,比较不同感染部位患者、不同感染病菌患者血清PCT及D-二聚体水平。结果:不同感染部位患者血清PCT及D-二聚体水平不同,血液感染患者的PCT及D-二聚体水平较其他部位感染患者明显增高,差异具有统计学意义(P<0.05);在不同病原菌的感染中,PCT由高至低分别为G-菌、G+菌、真菌,差异均具有统计学意义(P<0.05);真菌感染患者的D-二聚体水平与G-菌和G+菌感染患者相比,差异具有统计学意义(P<0.05),而G+菌和G-菌感染患者的血清D-二聚体水平比较差异无统计学意义(P>0.05)。结论:监测血清PCT和D-二聚体可能对明确脓毒症患者感染部位和感染病原菌提供参考,并对抗菌药物选择及疗程有一定指导意义。
Objective： To investigate serum procalcitonin and d-dimer level of different parts and various pathogenic microorganism infections caused sepsis. Methods： 116 sepsis patients＇ data were analyzed; comparing serum procalcitonin and d-dimer level of different parts and various pathogenic microorganism infections. Results： The values of procalcitonin and D-dimer in patients with bloodstream infection are significantly higher than in patients with other infection,difference was statistically significant（ P〈0. 05）. The PCT levels were different among different pathogens,top-to-bottom sequence as G-fungus,G ＋ fungus,and fungus,difference was statistically significant（ P〈0. 05）. Comparing Ddimer level of fungus infected patients with G-fungus and G ＋ fungus infected patients,difference was statistically significant（ P〈0. 05）; while serum D-dimer level comparison of G ＋ fungus and G-fungus infected patients showed no statistical significance（ P〈0. 05）. Conclusions： Monitoring serum PCT and D-dimer may be helpful to determine the infection parts and to definite the pathogens in sepsis patients,and be preferable for choosing antimicrobial agents.
作者
汪颖
王迪芬
刘颖
付江泉
陈先俊
WANG Ying WANG Difen LIU Ying FU Jiangquan CHEN Xianjun(Department of Critical Care Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, Chin)
出处
《贵州医科大学学报》
CAS
2017年第10期1164-1167,共4页
Journal of Guizhou Medical University
基金
贵州省科技攻关项目[黔科合SY(2010)3079号]
贵州省高层次人才科研项目(TZJF-2011-25)
国家临床重点专科建设项目(2011-170)
贵州省临床重点学科建设项目(2011-52)
作者简介
通信作者E-mail：dfwan@yahoo．com.cn
