摘要
目的 系统评估低剂量电离辐射对我国放射工作人员甲状腺功能的影响.方法 检索自1996—2017年来国内外正式刊物上发表的有关文献,严格按照预先设定的纳入和排除标准筛选文献,最终纳入15篇,共计6332人.分析放射工作人员甲状腺功能中血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）和促甲状腺素（TSH）水平.用Stata 14.0软件进行Meta分析.结果 随机效应模型分析结果显示,放射工作人员T3水平的标准化均数差（SMD）为-0.32[95%CI（-0.61,-0.04）,P=0.03],与对照组相比有降低的危险性;单个协变量Meta回归对异质性来源进行分析仅显示性别组成与研究间异质性有关,调整研究后方差的解释比率（adjusted R-squared,Adj R2）为29.99%（P=0.03）.T4水平的SMD为-0.49[95%CI（-0.94,-0.03）,P=0.04],与对照组相比有降低的危险性;单个协变量Meta回归对异质性来源进行分析仅显示性别组成与研究间异质性有关：Adj R2为26.60%（P=0.02）.TSH水平的SMD为1.10[95%CI（0.32,1.89）,P=0.006],与对照组相比有升高的危险性.结论 长期暴露在低剂量电离辐射环境中可能对放射工作人员甲状腺功能造成不良影响,应该进一步加强对放射工作人员甲状腺的辐射防护.
Objective To explore the effect of low dose ionizing radiation on the thyroid of radiation workers in our country. Methods The literatures were searched of domestic and foreign journals from 1996 to 2017. A total of 15 studies involving 6332 participants were included. These studies were screened according to the inclusion and exclusion criteria. Three indicators of the thyroid function were analyzed in radiation workers, including triiodothyronine （ T3 ） , thyroxine （ T4 ） and thyroid stimulating hormone（ TSH） . The Meta analysis was performed using Stata 14. 0 software. Results For radiation workers, the standardized mean difference （SMD） of T3 levels was -0. 32[95% CI （ -0. 61,-0. 04）, P=0. 03？, lower than that of the control group. Univariate meta - regression analysis of sources of heterogeneity showed that only gender composition was related to heterogeneity of the study [ adjusted R-squared （Adj R2 ） =29. 99%, P =0. 03]. The SMD of T4 levels was -0. 49 [95%CI （ -0. 94,-0. 03）, P=0. 04], lower than that of the control group. Only the gender composition was related to heterogeneity of the study[Adj R2 =26. 60%, P=0. 02]. However, the SMD of TSH levels was 1. 10 [95% CI （0. 32,1. 89）, P=0. 006], higher than that of the control group. Conclusions The long term exposure of radiation workers to low dose ionizing radiation may lead to negative impact on thyroid. It is important to strengthen radiation protection of thyroid.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2017年第10期777-785,共9页
Chinese Journal of Radiological Medicine and Protection
作者简介
通信作者：涂彧，Emai!：tuyu@suda．edu．cn
