摘要
目的探讨低剂量促性腺激素(Gn)联合克罗米芬全程使用的卵巢刺激方案在卵巢功能正常患者体外受精治疗中的应用价值。方法回顾性分析2013年1月1日至2015年6月30日江苏省人民医院生殖医学中心进行IVF/ICSI治疗,使用低剂量Gn联合克罗米芬全程使用的卵巢刺激方案周期1 063个,根据实际取卵次数分成4个组分别为A组(第1次取卵周期),B组(第2次取卵周期),C组(第3次取卵周期),D组(第4次取卵周期)。比较各取卵周期间患者年龄、Gn天数及用量、获卵数、受精率、优胚率、种植率、累积临床妊娠率、流产率及活产率等指标。结果不同取卵周期间患者的年龄、Gn天数、用量、获卵数、受精率、种植率及妊娠结局等方面差异均无统计学意义(P>0.05);D组的优胚率及多胎妊娠率较A、B、C组升高,差异有统计学意义(P<0.05);种植率(38.7%~46.67%)、累积活产率(50%~64.84%),与以往常规刺激周期相比,无显著性差异。结论低剂量Gn联合克罗米芬全程使用的卵巢刺激方案是行之有效的促排卵方案,反复IVF/ICSI失败的卵巢功能正常患者可考虑尝试低剂量Gn联合克罗米芬全程使用的卵巢刺激方案治疗。
Objective: To investigate the mild ovarian stimulation protocol with clomiphene citrate and low-dose gonadotropin(Gn)in IVF/ICSI cycles of the patients with normal ovarian function.Methods: The data of 1063 IVF/ICSI cycles with mild ovarian stimulation protocol by using clomiphene citrate and low-dose Gn in the patients with normal ovarian function in our clinical center of reproductive medicine from Jan.1 2013 to Jun.30 2015 were retrospectively analyzed.According to the actual frequency of oocyte retrieved,the cycles were divided into four groups.The patient's age,the dosage and duration of Gn used,number of oocyte retrieved,fertilization rate,high-quality embryo rate,implantation rate,accumulative clinical pregnancy rate,abortion rate,delivery rate were compared among the groups.Results: There were no significant differences in Gn dosage and duration,number of oocyte retrieved,fertilization rate,implantation rate,OHSS incidence,cumulative clinical pregnancy rate,abortion rate,ectopic pregnancy rate and live birth rate among the four groups.The high-quality embryo rate and multiple pregnancy rate were significantly higher in the fourth cycle than those in other three groups(P<0.05).Conclusions: The mild ovarian stimulation with clomiphene citrate and low-dose Gn is a practical and effective protocol for ovulation induction,which may be considered for the patients with ovarian function and repeated IVF/ICSI failure.
出处
《生殖医学杂志》
CAS
2017年第10期961-966,共6页
Journal of Reproductive Medicine
基金
国家自然科学基金青年基金(81200439)
江苏省"六大人才高峰"资助项目(2013-WSW-025)
作者简介
黄存,女,安徽马鞍山人,主治医师,生殖医学专业.
（通讯作者,Email：jsivf111126.com）
