摘要
目的探讨非那雄胺与多沙唑嗪联合应用对老年良性前列腺增生(BPH)夜尿症状的影响。方法选取2014年5月-2016年5月我院收治的96例BPH患者作为研究对象,按其治疗方法及临床特征将其分为对照组和观察组,每组48例,对照组于前列腺增生常规治疗上加以非那雄胺治疗,观察组于对照组基础上加用多沙唑嗪治疗,治疗结束后比较两组患者的夜尿次数、生活质量评分(QOL)、最大尿流率(Qmax)、国际前列腺症状评分(IPSS)和临床疗效及治疗过程中发生的不良反应。结果两组患者治疗后其夜尿次数较治疗前明显减少,Qmax较治疗前明显增加,且观察组减少、增加程度较对照组大,差异有统计学意义(P<0.05);两组治疗后QOL评分和IPSS评分均较治疗前降低,且观察组降低程度明显大于对照组(P<0.05);观察组临床总有效率(93.75%)明显高于对照组(79.17%)(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论非那雄胺联合多沙唑嗪可明显减少老年BPH患者夜尿次数,改善患者BPH相关临床指标,具有良好的临床疗效及安全性。
Objective To investigate the effects of finasteride combined with doxazosin on benign prostatic hyperplasia（ BPH） patients with nocturia.Methods A total of 96 cases of BPH treated in our hospital between May 2014 and May 2016 were selected as subjects.Based on their treatment methods and clinical characteristics,these patients were divided into the control group and observation group,48 cases in each group.The control group was given routine treatment for benign prostatic hyperplasia plus finasteride treatment while the observation group was additionally given doxazosin.After treatment,the number of times of nocturia,QOL score,maximum urinary flow rate（ Qmax）,IPSS score,clinical efficacy and adverse reactions were compared between the two groups.Results The number of times of nocturia in the two groups was significantly reduced after treatment,but Qmax was significantly increased,especially in the observation group,and the difference was of statistical significance（ P 〈0.05）.The QOL score and IPSS score of the two groups decreased after treatment,especially in the observation group（ P〈0.05）.The total effective rate（ 93.75%） in the observation group was significantly higher than that in the control group（ 79.17%）（ P〈0.05）.However,there was no difference in the incidence of adverse reactions between the two groups（ P〉0.05）.Conclusion Finasteride combined with doxazosin can significantly reduce the frequency of nocturia among elderly BPH patients,improve clinical indexes of patients with BPH,and has good clinical efficacy and safety.
出处
《解放军预防医学杂志》
CAS
2017年第7期793-795,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
四川省科学技术发展项目(No.20147629076HM)
作者简介
殷波（1982-）男,大学本科,主治医师.从事泌尿外科相关疾病诊治工作.
