摘要
目的研究维药阿里红多糖对运动疲劳小鼠Th1/Th2平衡、Foxp3 mRNA及Foxp3 Scurfin蛋白表达调控作用。方法采用递增负荷运动制备小鼠运动疲劳模型,给予不同浓度阿里红多糖,观察阿里红多糖对各组小鼠Th1/Th2平衡及Foxp3 Scurfin蛋白表达的影响。结果阿里红多糖可有效调节运动疲劳小鼠血清Th1/Th2相关细胞因子水平,维持T淋巴细胞免疫平衡,显著提高运动疲劳小鼠脾脏Foxp 3 mRNA表达量及Foxp3 Scurfin蛋白表达水平。结论维药阿里红多糖多糖有显著的抗疲劳、增强免疫作用。
Objective To study the effect of the polysaccharide from Fomes officinalis Ames on control of Th1/Th2 balance and expression of Foxp3 mRNA and Foxp3 Scurfin in erercise-induced physical fatigue mice. Methods The exercise-induced physical fatigue mice were administered with different concentrations of the polysaccharide from Fomes officinalis Ames by gavage. The effect of the polysaccharide on Th1/Th2 balance and Foxp3 Scurfin protein expression were observed. Results The levels of Th1/Th2 related cytokines were regulated effectively by the polysaccharide from Fomes officinalis Ames. Under the effect of the polysaccharide, the expression of Foxp 3 mRNA and Foxp3 Scurfin protein increased markedly and the Th1/Th2 balance was well maintained. Conclusion The polysaccharide from Fomes officinalis Ames has significant anti-fatigue and immunological effect.
作者
孔海军
王凤华
孔令生
黄玲
KONG Hai-jun WANG Feng-hua KONG Ling-sheng HUANG Ling(School of Physical Education of Xinjiang Normal University, Urumqi 830054, China Shandong University of Traditional Chinese Medicine, Jinan 250031, China Jinan Adicon Clinical Laboratories Inc, Jinan 250031, China)
出处
《食品与药品》
CAS
2017年第5期305-309,共5页
Food and Drug
基金
国家自然科学基金(编号31660736)
2016年新疆维吾尔自治区研究生科研创新项目(编号XJGRI2016106)
作者简介
孔海军（1992-），男，硕士研究生，从事运动医学研究E-mail：konghaijun1992@163．com
通讯作者：王凤华（1971-），女，博士，副教授，从事生物学研究E-mail：1057033469@qq．com
