摘要
目的:探讨糖尿病视网膜病变患者血清炎症因子、脂肪因子及氧化应激指标的水平变化。方法:选取我院收治的2型糖尿病患者130例,分为糖尿病无视网膜病变组(NDR)41例、非增殖期视网膜病变组(NPDR)44例和增殖期视网膜病变组(PDR)45例,另选取同期于我院体检的健康志愿者40名作为对照组(NC),检测各组的血清IL-6、TNF-α、hs-CRP、瘦素、脂联素、MDA和SOD水平。结果:各组IL-6、TNF-α、hs-CRP水平比较差异有统计学意义(P<0.05);PDR组均显著高于NC组、NDR组、NPDR组,NPDR组均显著高于NC组、NDR组,NDR组均显著高于NC组,差异均有统计学意义(P<0.05)。各组瘦素、脂联素水平比较,差异有统计学意义(P<0.05),PDR组瘦素高于NC组、NDR组、NPDR组,脂联素低于NC组、NDR组、NPDR组,NPDR组瘦素高于NC组、NDR组,脂联素低于NC组、NDR组,NDR组瘦素高于,脂联素低于NC组,差异均有统计学意义(P<0.05)。各组MDA、SOD水平比较差异有统计学意义(P<0.05),PDR组MDA高于NC组、NDR组、NPDR组,SOD低于NC组、NDR组、NPDR组,NPDR组MDA高于NC组、NDR组,SOD低于NC组、NDR组,NDR组MDA高于NC组,SOD低于NC组,差异均有统计学意义(P<0.05)。结论:糖尿病视网膜病变与炎症因子、脂肪因子及氧化应激指标具有密切关联。
Objective： To investigate the changes of serum inflammatory factors, adipokines and oxidative stress in patients with diabetic retinopathy. Methods： A total of 130 patients with type 2 diabetes mellitus admitted to our hospital were selected and divided into 41 cases with diabetic retinopathy （NDR）, 44 cases with nonproliferative retinopathy （NPDR） and 45 cases with proliferative retinopathy group （PDR）. Besides, 40 healthy volunteers in our hospital were selected as control group （NC）. The serum levels of IL-6, TNF-α, hs-CRP, leptin, adiponectin, MDA and SOD were detected. Results.. There were significant differences in the levels of IL-6, TNF-α and hs-CRP in groups （P 〈0.05）. The levels of IL-6, TNF-α and hs-CRP in PDR group were （18.19±3.84） pg/mL, （197.48±13.78） ng/L and （8.13±0.74） mg/L, respectively, which were significantly higher than those in NC group, NDR group and NPDR group. The levels of IL-6, TNF-α and hs-CRP in NPDR group were （14.07±3.62） pg/mL, （115.29±20.08） ng/L and （5.62±0.83） mg/L, respectively, which were significantly higher than those in NC and NDR groups. As for these levels in NDR group, they were（12.67±3.93） pg/mL,（89.49±10.49）ng/L and（3. 91±0.49）mg/L, respectively, which were significantly higher than those in NC group. The difference was statistically significant（P〈0.05）. There were significant differences among groups of leptin and adiponectin （P〈0.05）. The leptin level in PDR group was （23.19±6.48） μg/mL, which was significantly higher than that in NC group, NDR group and NPDR group. How ever, adiponectin was （3.70±1.02） g/mL, which was lower than those in other three groups. The level of leptin in NPDR group was higher than those in NC group and NDR group while adiponectin was lower than the two groups. Leptin level in NDR group was significantly higher than that in NC group while adiponectin was lower than that in NC group. The differences were statistically significant （P〈0.05）. Moreover, the levels of MDA and SOD in each group were significantly different （P 〈 0.05）. MDA in PDR group was （17.77±4.33） nmol / mL, which was higher than NC group, NDR group and NPDR group, but SOD was （62.35±11.43） U/mL, lower than those in these three groups. MDA in NPDR group was higher than NC group and NDR group but SOD was lower than NC group and NDR group. MDA level in NDR group was higher than that in NC group while SOD in NDR group was lower than that in NC group （P 〈0.05）. Conclusions.. Diabetic retinopathy is closely related to inflammatory factors, adipokines and oxidative stress.
出处
《海南医学院学报》
CAS
2017年第15期2048-2051,共4页
Journal of Hainan Medical University
基金
新疆维吾尔自治区自然科学基金(2016119D187)
作者简介
努荣古丽·买买提（1979-），女，维吾尔族，本科，主治医师，电话：15276688690，E—mail：nu20349@163．com。
[通讯作者]艾合买提江·吐乎提，男，维吾尔族，研究生学历，副主任医师。
