摘要
目的探讨血浆可溶性髓系细胞触发受体-1(Soluble myeloid triggering receptor expressed on myeloid cell-1,sTREM-1)及血清和脑脊液神经特异性烯醇化酶(neuro-specific enolase,NSE)水平在EV71型手足口病患儿病情判断中的价值。方法选取2012年2月—2014年2月来泰山医学院附属医院进行治疗EV71型手足口病患儿100例,选择同一时间来该院进行体检的健康儿童作为对照组。分析比较感染儿童和健康儿童血浆sTREM-1水平和血清NSE水平;比较不同分期和分型感染儿童血浆sTREM-1水平和血清和脑脊液中NSE水平。结果不同分期比较显示,急性期患儿sTREM-1水平、血清和脑脊液中NSE水平均显著高于恢复期患儿[(57.26±10.16)pg/mL vs(34.43±9.24)pg/mL,(18.46±3.47)ng/mL vs(15.21±3.24)ng/mL,(10.87±4.75)ng/mL vs(5.75±2.19)ng/mL,(P<0.05)];感染组重症患儿sTREM-1水平、血清和脑脊液中NSE水平均显著高于普通患儿[(56.26±9.16)pg/mL vs(29.65±8.45)pg/mL,(20.46±6.47)ng/mL vs(14.35±5.32)ng/mL,(11.87±4.75)ng/mL vs(4.76±1.26)ng/mL,(P<0.05)]。恢复期重症组患儿sTREM-1水平、血清和脑脊液中NSE水平均显著高于恢复期普通组患儿[(36.24±8.26)pg/mL vs(19.42±4.42)pg/mL,(16.46±5.24)ng/mL vs(13.24±3.56)ng/mL,(8.18±3.21)ng/mL vs(4.14±1.20)ng/mL,(P<0.05)]。结论 EV71型手足口患儿血浆sTREM-1及血清和脑脊液NSE水平的上升均指向病情恶化。对这两种生化指标的检测可以帮助对患儿病情进行预测。
Objective To study the value of plasma sTREM-1 and serum and cerebrospinal fluid NSE level in the disease identification of EV71-type hand-foot-and-mouth diseases. Methods 100 cases of children with EV71-type hand-foot-and-mouth diseases treated in our hospital from February 2012 to February 2014 were selected and the children with healthy physical examination in our hospital at the same period were selected as the control group, and the plasma sTREM-1 level and serum NSE level of infection children and healthy children were analyzed and the plasma sTREM-1 and serum and cerebrospinal fluid NSE level of different stages and different infection types were compared. Results The sTREM-1 level, serum and cerebrospinal fluid NSE level in the acute-staged children were obviously higher than those in the recovery-staged children[（57.26±10.16）pg/mL vs（34.43±9.24）pg/mL,（18.46±3.47）ng/mL vs（15.21±3.24）ng/mL,（10.87±4.75）ng/mL vs（5.75±2.19）ng/mL,（P〈0.05）], and the sTREM-1 level and serum and cerebrospinal fluid NSE level in the infection group were obviously higher than those in the common children [（56.26±9.16）pg/mL vs（29.65±8.45）pg/mL,（20.46±6.47）ng/mL vs（14.35±5.32）ng/mL,（11.87±4.75）ng/mL vs（4.76±1.26）ng/mL,（P〈0.05）], and the sTREM-1 level and serum and cerebrospinal fluid NSE level in the recovery-staged severe group were obviously higher than those in the recovery-staged common group[（36.24±8.26）pg/mL vs（19.42±4.42）pg/mL,（16.46±5.24）ng/mL vs（13.24±3.56）ng/mL,（8.18±3.21）ng/mL vs（4.14±1.20）ng/mL（ P〈0.05）]. Conclusion The increase of plasma sTREM-1 and serum and cerebrospinal fluid NSE level in the disease identification of EV71-type hand-foot-and-mouth diseases is caused by the disease progression, and these two biochemical indexes test can help predict the disease condition of children.
出处
《系统医学》
2017年第11期83-86,共4页
Systems Medicine
关键词
可溶性髓系细胞触发受体-1
神经特异性烯醇化酶
手足口病
Soluble triggering receptor expressed on myeloid cells-Ⅰ
Neuron specific enolase
Hand-foot-and-mouth diseases
作者简介
郭强（1968-）,男,山东泰安人,本科,副主任医师,研究方向感染性疾病的诊断和治疗.
