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胃肠道间质瘤中Ki-67表达及其与临床病理特征、危险度分级的相关性 被引量:24

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摘要 目的探讨Ki-67在胃肠道间质瘤(gastrointestinal stromal tumors,GIST)中的表达及其与临床病理特征、危险度分级的相关性。方法分析77例手术切除的原发性GIST患者的临床病理资料,采用免疫组化SP法检测Ki-67的表达,分析其表达与GIST的临床病理特征及危险度分级的相关性。结果Ki-67表达在肿瘤部位、核分裂象、危险度分级中,差异有统计学意义(P<0.05);在患者年龄、性别、肿瘤大小、组织类型、囊性变、单发或多发、出血、坏死及合并其他肿瘤中,差异无统计学意义(P>0.05);Ki-67增殖指数与肿瘤部位、核分裂象、单发或多发及危险度分级有相关性(P<0.05),其中Ki-67增殖指数与核分裂象及危险度分级呈正相关。结论Ki-67增殖指数可作为判断GIST危险度分级及预后预测的重要参考指标。
出处 《临床与实验病理学杂志》 CSCD 北大核心 2017年第9期1022-1025,共4页 Chinese Journal of Clinical and Experimental Pathology
作者简介 王帆荣,女,硕士研究生。E—mail:659090960@qq.com 张丽娟,女,副教授,硕士生导师,通讯作者。E-mail:13769171381@163.com
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