摘要
目的探讨血液灌流(haemoperfusion,HP)对高血脂的清除作用及对急性高脂血症性胰腺炎(hypertriglyceridemia-induced acute pancreatitis,HTG-AP)的治疗作用。方法回顾性分析了HP治疗HTG-AP患者12例,在常规治疗的基础上给予HP治疗。分析血脂下降水平、临床表现、局部和全身并发症发生情况,住院天数和住院死亡率。结果 12例HTG-AP患者,入院时三酰甘油(triglyceride,TG)水平为(54.542±19.019)mmol/L、血浆胆固醇(cholesterol,CHOL)水平为(13.158±5.242)mmol/L,第1次HP后TG下降至(12.957±9.934)mmol/L,下降率(77.740±11.668)%,t=6.714,P<0.001;CHOL下降至(8.294±6.960)mmol/L,下降率(36.482±12.783)%,t=2.605,P=0.016。有5例患者在次日接受第2次HP治疗使得TG下降至10mmol/L以下。在1~3天内,所有患者的TG水平在5.65mmol/L以下。重症医学科(Intensive care unit,ICU)治疗(2.917±1.730)d,住院日(11.500±8.939)d。住院死亡率为0。结论 HP能够有效地降低HTG-AP患者的血脂水平,改善患者的临床结局。
Objective To evaluate the effects of hemoperfusion （HP） for the treatment of hyperlipidemia and hypertriglyceridemia- induced acute pancreatitis （HTG- AP）. Methods Twelve patients suffering from HTG-AP were retrospectively analyzed. They were treated with HP in addition to routine treatment. The improvement of hyperlipidemia, clinical symptoms, local and systemic complications, hospitalization days and mortality rate were analyzed. Results In the 12 patients at the time of admission, serum triglyceride （TG） was 54.542±19.019 mmol/L, and serum cholesterol （CHOL） was 13.158±5.242 mmol/L. After the first session of HP, serum TG reduced to 12.957±9.934 mmol/L （reduction rate of 77.740±11.668%, P〈0.001） and serum CHOL reduced to 8.294±6.960 mmol/L （reduction rate of 36.482±12.783%, P=0.016）. Five of the 12 patients reached a TG level 〈10 mmol/L after two sessions of HP, and all of the patients had the serum TG level 〈 5.65 mmol/L within 1-3 days. The duration in ICU was 2.917±1.730 days, and hospitalization period was 11.500±8.939 days. None of them died. Conclusion HP can effectively reduce serum TG level and improve clinical outcomes in HTG-AP patients.
出处
《中国血液净化》
2017年第9期587-591,共5页
Chinese Journal of Blood Purification
基金
厦门市卫生和计划生育委员会资助研究经费
福建省医学创新课题<超声指导感染性休克患者循环管理的研究>项目编号:2015-CXB-48
关键词
血液灌流
急性高脂血症性胰腺炎
三酰甘油
疗效
Hemoperfusion
Hypertriglyceridemia-induced acute pancreatitis
Serum triglyceride concentration
Therapeutic effect
作者简介
通讯作者：陈辉民361100厦门，厦门市第三医院重症医学科Email：102300xm@163．com
