摘要
目的 用Meta分析方法对常见妇科恶性肿瘤患者经治疗后出现下肢淋巴水肿的多个危险因素进行系统分析、定量综合研究。方法 从PubMed、EMbase、Cochrane图书馆等英文数据库里检索自建库至2016年8月发表的临床研究,纳入文献经NOS质量评价后通过Stata 14.0以及RevMan 5.3软件进行数据分析,通过分析各危险因素的OR值及其95%CI评价其关联强度。结果 最终纳入18篇文献,筛查出8个相关因素,其中放疗（OR=2.45,95%CI为2.05~2.94,P=0.000）、FIGO分期（OR=2.29,95%CI为1.66~3.14,P=0.000）及盆腔淋巴结清扫（OR=2.00,95%CI为1.02~3.91,P=0.040）为危险因素。结论 放疗、FIGO分期、盆腔淋巴结清扫是妇科恶性肿瘤经治疗后下肢淋巴水肿发生的主要危险因素。
Objective To investigate the multiple risk factors for lower extremity lymphedcma in patients following treatment of common gynecologic cancers by meta-analysis for systcmatic analysis and comprehensive quantitative study. Methods Clinical trials published up until August 2016 were retrieved from PubMed, Embase, and the Cochrane Library. The quality of the included studies was assessed by the Newcastle-Ottawa Scale, and data analysis was performed using Stata 14.0 and RevMan 5.3. The strength of the associations between risk factors and gynecologic cancer-related lower extremity lymphedcma was described as odds ratio （OR） and 95% confidence intervals （CI）. Results Eighteen studies were included in the meta-analysis, and 8 relevant factors were identified. The risk factors for lower extremity lymphedcma after treatment of gynecologic cancer mainly included radiotherapy （OR=2.45, 95%CI：2.05-2.95, P=0.000）, FIGO stage （OR=2.29, 95%CI：1.66-3.14, P=0.000）, and pelvic lymph node dissection （OR=2.00, 95%CI：1.02-3.91, P=0.040）. Conclusions Radiotherapy, FIGO stage, and pelvic lymph node dissection are the main risk factors for lower extremity lymphedcma after treatment of gynecologic cancers.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2017年第9期1038-1044,共7页
Chinese Journal of Radiation Oncology
关键词
妇科肿瘤
下肢淋巴水肿
危险因素
Gynaeeological neoplasms
Lower extremity lymphedcma
Risk factors
作者简介
通信作者：庄志祥，Email：sdfeyzzx@sina．Com
