摘要
目的:分析万古霉素致药物不良反应(ADR)的原因与特点,为临床规范合理使用万古霉素提供参考。方法方法:利用万方数据库,检索"万古霉素""不良反应"为检索词,剔除同一病例不同文献的重复的以及病例资料不全的文献,筛选出41例万古霉素致不良反应病例文献,并对其ADR发生的原因和特点作了分析。结果:万古霉素导致不良反应主要有变态反应(48.78%)、肾毒性(14.63%)、白细胞减少(12.20%)等;另有肝损害、第8脑神经、皮肤黏膜综合征、四肢颤抖等也有报道。结论:万古霉素致不良反应较多,应规范其用法用量及对可能出现的不良反应进行监测。
Objective： To analyze the causes and characteristics of adverse drug reactions（ADRs） caused by Vancomycin and to Provide a reference for clinical rational use of vancomycin. Methods： The articles published in Wanfang Database are retrieved by searching the word Vancomycin and adverse drug reaction. And are eliminated the repeated reports in different literature and the case whose data are not enough comprehensive. A total of 41 patients of vancomycin cases of adverse reactions are selected to analyze and statistics to make finally. Results： The adverse drug reactions of the use of vancomycin mainly include allergy reaction （48.78%）, kidney damage （14.63%） and leukopenia （12.20%）. In addition,cases about liver danaage, the eighth cranial nerves damage, a syndrome of skin and mucosa, limb tremors have been also reported. Conclusion： Since the adverse drug reactions of vancomycin are general, the usage and dosage of vancomycin should be regulated and its possible adverse reactions should be monitored timely.
出处
《抗感染药学》
2017年第4期804-807,共4页
Anti-infection Pharmacy
基金
中山市科学技术基金项目(编号:2014A1FC151)
作者简介
邱雄泉（1972-）,男，主任药师
[通信作者]陈晓坚（1990-），女，在读硕士研究生，药师[联系电话]：13802668925 E-mail：joeky@163.com
