摘要
目的系统评价血管内皮生长因子(VEGF)在中国三阴性乳腺癌(TNBC)患者中的表达情况以及其阳性表达与TNBC患者临床病理特征的关系。方法通过中国知网、万方数据库、维普、中国生物医学数据库、超星Medalink和Pub Med数据库检索已发表的有关关于中国TNBC患者的相关文献资料,由2名研究者按照纳入与排除标准独立筛选文献、提取资料和文献评价,然后使用Rev Man 5.3软件进行meta分析。结果本研究纳入11篇相关文献共1 838例患者,其中TNBC患者750例,非TNBC患者1 088例。meta分析结果显示,VEGF蛋白表达阳性率在TNBC患者中明显高于非TNBC患者[OR=2.64,95%CI(2.14,3.26),P<0.000 01]。在TNBC患者中,VEGF蛋白表达阳性率在淋巴结(+)患者中明显高于淋巴结(–)患者[OR=0.30,95%CI(0.14,0.46),P=0.000 2]、在Ⅲ–Ⅳ期患者中明显高于Ⅰ–Ⅱ期患者[OR=0.43,95%CI(0.29,0.62),P<0.000 01],其与TNBC患者的年龄[OR=0.80,95%CI(0.54,1.19),P=0.27]和肿瘤大小[OR=0.84,95%CI(0.53,1.33),P=0.46]无关。结论 VEGF蛋白在TNBC患者中呈高表达,有望成为其治疗的新靶点;且其蛋白阳性表达与TNBC患者的阳性淋巴结及TNM分期晚有关,其可能与TNBC患者的预后有一定的关系。
Objective To systematically evaluate expression of vascular endothelial growth factor （VEGF） protein in triple negative breast cancer （TNBC） and analyze its correlation between positive expression of VEGF protein and clinicopathologic features of patient with TNBC. Methods The published literatures relevant VEGF protein expression in TNBC and its relation to clinicopathologic features of patient with TNBC in China were retrieved by means of CNKI, Wanfang, VIP, China Biomedical, Chaoxing Medalink, PubMed databases, and other search tools. The literatures were independently filtered, extracted, and assessed by two reviewers according to the inclusion criteria and exclusion criteria. The meta-analysis was conducted by using RevMan 5.3 software. Results A total of 11 literatures were included and involved I 838 patients （750 patients in the TNBC group and 1 088 patients in the non-TNBC group）. The results of meta- nalysis showed that the positive expression of VEGF protein in the TNBC group was significantly higher than that in the non-TNBC group [ OR=2.64, 95%CI （2.14, 3.26）, P〈0.000 01 ）, which was significantly increased in the TNBC patients with positive lymph node or stage Ⅲ-Ⅳ as compared with the negative lymph node or stage Ⅰ - Ⅱ [OR=0.30, 95% CI （0.14, 0.46）, P=0.000 2; OR=0.43, 95% CI （0.29, 0.62）, P〈0.000 011. However, the positive expression of VEGF protein was no associated with the age of patients with TNBC or tumor size （P〉0.05）. Conclusions VEGF highly expresses in TNBC and it is expected to be a new therapeutic target. Positive expression of VEGF protein is related to positive lymph node and late TNM stage, and it might be associated with prognosis of patient with TNBC.
出处
《中国普外基础与临床杂志》
CAS
2017年第8期992-999,共8页
Chinese Journal of Bases and Clinics In General Surgery
关键词
三阴性乳腺癌
血管内皮生长因子
META分析
triple negative breast cancer
vascular endothelial growth factor
meta-analysis
作者简介
通信作者：地力木拉提·艾斯木吐拉，Email：2499156828@qq．com
