摘要
目的探讨血清C肽水平与2型糖尿病患者大血管病变间的关系。方法回顾性分析96例2型糖尿病患者的临床资料,根据患者是否伴有大血管病变将其分为糖尿病大血管病变组(观察组)和无糖尿病大血管病变组(对照组),分析2组患者的年龄、病程、血压、体质量指数(BMI)、空腹血糖(FBG)及餐后1 h血糖(PBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹C肽(FCP)、餐后1 h C肽(PCP)等各项指标的差异性。结果与对照组比较,观察组患者年龄较大,病程偏长(P<0.05);2组患者BMI和性别比较差异无统计学意义(P>0.05);观察组高血压患者的比例高于对照组(P<0.05);观察组患者的TG、LDL-C、FBG、PBG、Hb A1C水平显著高于对照组,HDL-C、FCP及PCP水平显著低于对照组(P<0.05);2组患者TC水平比较差异无统计学意义(P>0.05)。Logistic回归分析结果显示,年龄、病程、高血压、TG、LDL-C、FBG、PBG及Hb A1c为大血管病变的危险因素,HDL-C、FCP及PCP为大血管病变的保护性因素(P<0.05)。结论血清C肽水平的降低可能是导致2型糖尿病患者大血管病变发生、发展的因素之一,C肽可能对糖尿病患者大血管具有保护作用。
Objective To explore the relationship between the serum levels of C-peptide and macroangiopathy in patients with type 2 diabetes mellitus.Methods The clinical data of 96 patients with type 2 diabetes mellitus were analyzed retrospectively.All patients were divided into macroangiopathy group（observation group,n =44） and non macroangiopathy group （control group,n =52） according to wether the patients with macroangiopathy.The differences of the age,course of disease,blood pressure,body mass index （BMI）,fasting blood glucose （FBG）,postprandial hour blood-glucose （PBG）,hemoglobin A1 c （HbA 1 c）,total cholesterol （TC）,triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）,fasting C-peptide（FCP）,and postprandial C-peptide （PCP） of patients between the two groups were analyzed.Results Compared with the control group,the patients in the observation group had older age and longer course of disease （P 〈 0.05）.There was no statistic difference in the BMI and gender of patients between the two groups （P 〉 0.05）.The proportion of patients with hypertension in observation group was significantly higher than that in the control group （P 〈 0.05）.The levels of TG,LDL-C,FBG,PBG and HbA1C of patients in the observation group were significantly higher than those in the control group（P 〈 0.05）;the levels of HDL-C,FCP and PCP of patients in the observation group were significantly lower than those in the control group（P 〈 0.05）.There was no statistic difference in the TC levels of patients between the two groups （P 〉 0.05）.Logistic regression results showed that the age,course of disease,type 2 diabetes mellitus patients were the risk factors for the macroangiopathy,while the HDL-C,FCP and PCP were the protect factors for the macroangiopathy （P 〈 0.05）.Conclusion The decrease of C-peptide level in serum may promote the occurrence of macroangiopathy in patients with typc 2 diabetes mellitus,and C-peptides may have protective effect for great vessels in the patients with diabetes.
出处
《新乡医学院学报》
CAS
2017年第8期687-689,共3页
Journal of Xinxiang Medical University
基金
国家自然科学基金资助项目(编号:31500836)
安徽省自然科学基金资助项目(编号:1308085QH147
1608085QH176)
安徽省蚌埠医学院自然科学基金重点项目(编号:BYKY201622ZD
BYKY201635ZD)
关键词
2型糖尿病
大血管病变
C肽
type 2 diabetes mellitus
macroangiopathy disease
C-peptide
作者简介
王春（1982-），男，安徽舒城人，硕士，主治医师，讲师，研究方向：糖尿病慢性并发症的发病机制。
通信作者：黄丽（1982-），女，安徽淮南人，硕士，讲师，研究方向：神经内分泌分子机制；E-mail：zi05@163．com。
