摘要
目的分析胰岛素短期强化治疗初诊2型糖尿病的临床疗效。方法选择2016年1月至2016年12月濮阳市安阳地区医院收治的初诊2型糖尿病患者76例,分为对照组和观察组,每组38例。对照组患者给予门冬胰岛素治疗,观察组患者给予胰岛素泵强化治疗,2组疗程均为2周。检测并比较2组患者治疗前后血糖、血脂、糖化血红蛋白(Hb A1c)、超氧化物歧化酶(SOD)和丙二醛(MDA)水平,以及口服葡萄糖刺激后胰岛β细胞功能指标变化情况。结果治疗前,2组患者空腹血糖(FPG)、Hb A1c、总胆固醇(TC)、三酰甘油(TG)比较差异均无统计学意义(P>0.05);治疗后,2组患者FPG、Hb A1c、TC、TG较治疗前均显著下降,且观察组患者较对照组下降更显著(P<0.05)。治疗前,2组患者血清SOD活性和MDA水平比较差异无统计学意义(P>0.05);治疗后,2组患者血清SOD活性均较治疗前显著升高,MDA水平较治疗前显著降低,且观察组患者血清SOD活性高于对照组,MDA水平低于对照组(P<0.05)。治疗前,2组患者胰岛β细胞功能(HOMA-β)、胰岛素曲线下面积(AUC)、胰岛素抵抗(HOMA-IR)及30 min胰岛素浓度/血糖浓度(I_(30)/G_(30))比较差异均无统计学意义(P>0.05);治疗后,2组患者HOMA-β、AUC及I_(30)/G_(30)均较治疗前增加,HOMA-IR较治疗前降低,且观察组患者HOMA-β、AUC及I_(30)/G_(30)较对照组增加更显著,HOMA-IR较对照组下降更显著(P<0.05)。结论短期胰岛素泵强化治疗能显著改善2型糖尿病患者的血糖、血脂水平及胰岛β细胞功能。
Objective To study the clinical effect of intensive treatment of short-term insulin pump for the newly diagnosed patients with type 2 diabetic mellitus. Methods A total of 76 patients with newly diagnosed type 2 diabetic mellitus in Anyang District Hospital of Puyang City from January 2016 to December 2016 were selected and divided into control group and observation group,with 38 patients in each group. The patients in the control group were treated with insulin aspart; the patients in the observation group were treated with intensive treatment of short-term insulin pump; the course of treatment was 2 weeks in the two groups. The levels of plasma glucose,blood lipid,glycosylated hemoglobin（ Hb A1c）,superoxide dismutase（ SOD）,malondialdehyde（ MDA） and the indexes of islet β-cell function after oral glucose stimulation were detected and compared between the two groups before and after treatment. Results Before treatment,there was no statistic difference in the levels of fasting plasma glucose（ FPG）,Hb A1 c,total cholesterol（ TC）,triglyceride（ TG） between the two groups（ P〉0. 05）. After treatment,the levels of FPG,Hb A1 c,TC,TG in the two groups were significantly lower than those before treatment（ P〈0. 05）; and the levels of FPG,Hb A1 c,TC,TG in observation group were significantly lower than those in the control group（ P〈0. 05）. Before treatment,there was no statistic difference in the level of MDA,the activity of SOD between the two groups（ P〉0. 05）. After treatment,the activity of SOD in the two groups was significantly higher than that before treatment（ P〈0. 05）; the levels of MDA in the two groups were significantly lower than those before treatment（ P〈0. 05）; the activity of SOD in the observation group was significantly higher than that in the control group（ P〈0. 05）; the level of MDA in the observation group was significantly lower than that in the control group（ P〈0. 05）. Before treatment,there was no statistic difference in the homeostasis model assessment-β（ HOMA-β）,insulin area under the curve（ AUC）,Homeostasis model assessment-IR（ HOMA-IR） and insulin concentration/blood glucose concentration at 30 min（ I（30）/G（30）） between the two groups（ P〈0. 05）.Compared with before treatment,the HOMA-β,AUC and I（30）/G（30） were significantly increased,but the HOMA-IR was significantly decreased after treatment in the two groups（ P〉0. 05）. Compared with control group,the HOMA-β,AUC and I（30）/G（30） in the observation group were increased,and the HOMA-IR was decreased after treatment（ P〈0. 05）. Conclusion The intensive treatment of short-term insulin pump can obviously improve the levels of plasma glucose,blood lipid and the islet β-cells function in the patients with type 2 diabetic mellitus.
出处
《新乡医学院学报》
CAS
2017年第7期647-650,共4页
Journal of Xinxiang Medical University
关键词
2型糖尿病
胰岛素泵
短期强化治疗
胰岛Β细胞
type 2 diabetic mellitus
insulin pump
intensive treatment of short-term
islet β-cells
作者简介
周利霞（1972-），女，河南清丰人，学士，副主任医师，研究方向：心血管疾病的诊治。
