摘要
目的探讨补肾活血中药治疗骨质增生继发性腰痛疗效及对Wnt信号通路抑制剂1(DKK1)、骨硬化素蛋白(SOST)水平的影响。方法选取110例骨质增生继发性腰痛患者,分为对照组(55例)和观察组(55例),分别给予单纯西医治疗和联用补肾活血中药治疗,比较两组患者近期疗效、中医证候积分、简化Mc Gill量表评分、ODI评分、X射线检查评分、健康相关生活质量评分、DKK1、SOST水平及不良反应发生率等。结果观察组患者治疗后中医证候各积分明显均低于对照组,差异有统计学意义(t分别=2.77、3.91、4.06、3.50、2.69、3.07,P均<0.05);疼痛分级指数(PRI)、VAS、现时疼痛强度(PPI)评分亦明显低于对照组(t分别=3.18、2.91、3.55,P均<0.05);ODI评分、X射线检查评分及健康相关生活质量评分均明显优于对照组(t分别=3.07、3.54、2.98,P均<0.05);DKK1和SOST水平均明显高于对照组(t分别=2.85、3.16,P均<0.05)。两组患者不良反应发生率比较,差异无统计学意义(χ~2=1.34,P>0.05),但观察组总有效率优于对照组,差异有统计学意义(χ~2=8.29,P<0.05)。结论补肾活血中药治疗骨质增生继发性腰痛可有效改善临床症状,促进肢体活动功能恢复,提高日常生活质量,调节DKK1和SOST水平,但不增加不良反应发生风险。
Objective To investigate the effect of Bushen Huoxue prescription on secondary lumbago caused by bone hyperplasia and its effect on the levels of DKK1 and SOST. Methods Totally 110 patients with secondary lumbago caused by bone hyperplasia were selected and divided into the control group（55 cases） and the observation group（55 cases）. The control group was only given western medicine treatment,and the observation group was given Bushen Huoxue prescription on the basis of the western medicine treatment. The clinical effects for short-term,the TCM scores,simplified Mc Gill scale score,ODI score,X-ray examination score,the score of health related quality of life,DKK1 level,SOST level,and the adverse reaction incidence between two groups were compared. Results The TCM scores including six items of observation group after treatment were significantly lower than those of the control group（t= 2.77,3.91,4.06,3.50,2.69,3.07,P〈0.05）. The scores of PRI,VAS,and PPI of observation group after treatment were significantly lower than those of control group（t=3.18,2.91,3.55,P〈0.05）. The ODI score,X-ray examination score,and the score of health related quality of life of observation group after treatment were significantly better than control group（t=3.07,3.54,2.98,P〈0.05）. The levels of DKK1 and SOST of observation group after treatment were significantly higher than control group（t=2.85,3.16,P〈0.05）. There was no significant difference in the adverse reaction incidence between two groups（χ^2=1.34,P〉0.05）. The clinical efficacy for short-term of observation group were significantly better than control group（χ^2=8.29,P〈0.05）.Conclusion Bushen Huoxue prescription efficiently improve the clinical symptoms of secondary lumbago caused by bone hyperplasia,promote the recovery of limb function,improve the quality of daily life,regulate the level of DKK1 and SOST and do not increase the risk of adverse reactions.
作者
干群
GAN Qun.(Department of Orthopedics,TCM Hospital of Zhoushan City,Zhoushan 316000,China.)
出处
《全科医学临床与教育》
2017年第4期404-408,共5页
Clinical Education of General Practice
