摘要
骨质疏松症(osteoporosis,OP)是一种以低骨量和骨组织微结构破坏为特征,导致骨质脆性增加和易于骨折的全身性骨代谢性疾病。骨质疏松症患者最终结局常常是脆性骨折。骨质疏松症不利于骨折愈合,主要是由于骨质疏松症导致患者的骨吸收作用增强、新骨形成能力下降造成的。为了缩短骨质疏松症个体的骨折愈合时间、提高愈合质量,抑制骨吸收或促进骨形成的药物成为研究热点。而抗骨质疏松的治疗药物主要是通过抑制骨吸收或促进骨形成促进骨质疏松性骨折的愈合。所以现在已有大量的实验探讨了抗骨质疏松治疗药物对骨质疏松性骨折愈合的影响。同时还有关于抗骨质疏松药对骨修复影响的研究。这些研究的结果总结来说,指出了抗骨质疏松药可能对骨质疏松性骨折治疗有一定的作用。同时现在还没有明确的证据证明抗骨质疏松治疗不利于骨修复,故抗骨质疏松药在骨质疏松性骨折上有很大的应用前景。本文回顾综述了当下骨质疏松性骨折治疗的研究进展,总结了双膦酸盐、地诺单抗、雌激素、雷洛昔芬、特立帕肽、雷尼酸锶、他汀类药物以及一些正在研究中的抗骨质疏松药物对骨折愈合的影响及其作用机制。
Osteoporosis（OP） is a systemic metabolic bone disease with decreased bone mass and destructive micro-structure,and increases the risk of fracture.Patients with osteoporosis most possibly experience fragility fractures.Since osteoporosis can cause the enhancement of bone resorption and the decline of bone formation,it may have negative effect on the fracture healing.To decrease the fracture healing time in patients with osteoporosis and to improve the healing quality,drugs which can inhibit bone resorption or promote bone formation have become current hotspots.Anti-osteoporotic drugs can promote the osteoporotic fracture healing by inhibiting bone resorption or promoting bone formation.Therefore,there are many researches on the effect of anti-osteoporotic drugs on osteoporotic fractures and bone repair currently.In conclusion,the result of these researches show that anti-osteoporotic drugs may promote fracture healing.At the same time,there is no specific evidence proving that anti-osteoporotic drugs may affect the repair of bone.So,in the future anti-osteoporotic drugs can play a significant role in osteoporotic fracture.In this article,current researches of the treatment of the osteoporotic fracture and the mechanism of the drugs are reviewed.The anti-osteoporotic drugs include bisphosphonates,denosumab,estrogen,raloxifene,teriparatide,strontium ranelate,statins,and some drugs in research.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第7期947-953,共7页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81300858)
教育部博士点基金(20130181120090)
关键词
骨质疏松
骨折
药物治疗
骨形成
骨修复
Osteoporosis
Fracture
Medication
Bone formation
Bone repair
作者简介
通讯作者：李运峰，Email：doctorlyf@163．com
