摘要
目的评价高危HPVE6/E7mRNA在宫颈病变中的临床价值。方法将70例低度宫颈病变(慢性宫颈炎),子宫颈上皮内瘤变(CINI级)和78例高级别宫颈病变(包括CINⅡ级CINⅢ级和宫颈浸润性癌)分为两组。低度宫颈病变为对照组,高级别宫颈癌组为实验组。分别进行HPV DNA分型和HPV E6/E7 mRNA检测。结果低度子宫颈病变和高度子宫颈病变的阳性率分别为14.2%和79.5%。HPV DNA分型检测结果,低度子宫颈病变和高度子宫颈病变的阳性率分别为35.7%和85.7%。高风险HPV E6/E7 mRNA检测特异性,阳性预测值,阴性预测值(85.8%,86.1%,83.5%)显着高于(64.3%,70.5%,71.4%),差异有统计学意义。结论高危HPV E6/E7 mRNA检测有效降低了临床诊断中的过度检查和过度治疗的机会,避免了患者因高频重复感染引起的经济负担和精神压力。
Objective To evaluate the clinical value of high risk HPVE6/E7 mRNA in cervical lesions. Methods 70 patients with lower-grade cervical lesions （chronic cervicitis, cervical intraepithelial neoplasis, CINI-grade） and 78 patients with high-grade cervical lesions （including CIN Ⅱ grade, CIN Ⅲ grade and cervical invasive carcinoma） were divided into two groups. Lower-grade cervical lesions were set as the control group while high-grade cervical lesions were set as the experimental group. They were respectively given HPV DNA typing and HPVE6/E7 mRNA detection. Results Detection of high risk HPVE6/E7 mRNA. Positive rates of lower-grade cervical lesions and high- grade cervical lesions were respectively 14.2% and 79.5%. Detection results of HPV DNA typing. Positive rates of lower-grade cervical lesions and high-grade cervical lesions were respectively 35.7% and 85.7%. Specificity, positive predictive value and negative predictive value of high risk HPVE6/E7 mRNA detection were respectively 85.8%, 86.1% and 83.5%, significantly higher than those 64.3%, 70.5% and 71.4%. Difference was statistically significant. Conclusion High-risk HPVE6/E7 mRNA detection can effectively reduce the chance of over-examination and over- treatment in clinical diagnosis and avoid the economic burden and mental stress caused by high-frequency repeated infection.
出处
《中国医药科学》
2017年第12期19-22,共4页
China Medicine And Pharmacy
