摘要
建立了同时测定化妆品中7种含氮苯甲醚类化合物(邻氨基苯甲醚、间氨基苯甲醚、对氨基苯甲醚、2-硝基苯甲醚、3-硝基苯甲醚、4-硝基苯甲醚、3,3'-二甲氧基联苯胺)的液相色谱分析方法。样品用超纯水分散后以乙酸乙酯提取,经浓缩后,用PSA进行纯化,采用Diamonsil-C18色谱柱(250 mm×4.6 mm×5μm)分离。结果表明,7种含氮苯甲醚化合物在0.5~20.0 mg/L范围内的质量浓度与其响应之间线性关系良好,相关系数均大于0.992;方法检出限(S/N=3)在9.3~23.5μg/L之间;在化妆水和眼影粉状样品中进行3个水平的添加实验,平均回收率为80.3%~119.9%,相对标准偏差(n=6)在3.4%~6.4%之间。实际样品检测表明本方法准确可靠,适用于化妆品中苯甲醚类化合物的同时测定。
A new method was developed for the simultaneous determination of seven nitrogen containing phenyl ethers[o - Anisidine, m - Anisidine, p - Anisidine, 2 - Nitroanisole, 3 - Nitroanisole, 4 - Nitroanisole, 3,3＇ - Dimethoxybenzidine （3,3＇ - DMBD）] in cosmetics by high performance liquid chromatography （HPLC）. The samples were dispersed in ultra - pure water and extracted with ethyl acetate. After concentration, the samples were purified with PSA. Finally, the samples were separated on a Diamonsil - C 18 column （250mm×4.6mm×5μm）. The result indicated that seven analytes had good linear relationship （P 〉 0.992） at the concentrations of 0.05 - 20.0 mg/L. The detection limits of target compounds of this method （LODs, S/N=3） ranged from 9 to 230 μg/kg. The recoveries of seven nitrogen containing phenyl ethers were in the range of 80.3% to 119.9% at three spiked levels in samples of astringent and eye shadow, the relative standard deviations （RSDs, n = 6） ranged from 3.4% to 6.4%. The real sample analysis result showed that this accurate and precise method could be appropriate for simultaneous determination of seven nitrogen containing phenyl ethers in cosmetics.
作者
胡冬萍
黄嘉乐
林森煜
李秀英
王强
HU Dong - ping HUANG Jia - le LIN Sen - yu LI Xiu - ying WANG Qiang(Guangzhou Quality Supervision and Testing Institute, Guangzhou 511447, Guangdong, China)
出处
《香料香精化妆品》
CAS
2017年第3期20-25,共6页
Flavour Fragrance Cosmetics
基金
国家质量监督检验检疫总局科技计划项目(2015QK165)
作者简介
胡冬萍（1990-），女，硕士，工程师，主要研究方向：食品或化妆品中非法添加的有害物质检测。联系电话：13430355981E—mail：yuchi_hdp@163．com
