摘要
目的 探讨糖尿病肾病（DN）患者经前列地尔治疗时对其机体UAER、SCr、TNF-α及hs-CRP水平变化的影响.方法 选取2014年1月-2015年12月在天津市滨海新区大港医院进行诊治的110例DN患者,采用SPSS 16.0软件生成随机数字表分为前列地尔组（基础治疗＋前列地尔）、对照组（基础治疗）各55例,对比2组患者的临床疗效、炎性反应指标、氧化应激指标.结果 治疗后,前列地尔组患者的UAER、24h尿蛋白定量、血清MDA、8-OHdG、TNF-α、IL-18、ICAM-1、hs-CRP测定值均低于对照组（P〈0.05）;血清SOD、GSH-Px水平均高于对照组（P〈0.05）;前列地尔组糖尿病肾病患者临床治疗总有效率（92.73%）显著高于对照组（74.55%）,数据对比差异有统计学意义（P〈0.05）.结论 前列地尔辅助治疗DN患者的具有减轻患者炎症反应及氧化应激损伤的作用,对提高治疗效果具有积极作用.
Objective to investigate the effects of alprostadil on the levels of UAER, SCr, TNF-alpha and hs-CRP in patients with diabetic nephropathy （DN）.Methods110 cases with DN from January 2014 to December 2015 in Dagang hospital Tianjin Binhai New Areawere randomly divided into the alprostadil group（basic treatment＋alprostadil） and the control group （basic treatment）, 55 cases in each group.The clinical effect and the indexes of inflammatory reaction and oxidative stress were compared in the two groups.ResultsAfter treatment, UAER, 24h urinary protein, serum MDA, 8-OHdG, TNF-α, IL-18, ICAM-1, hs-CRP in the alprostadil group were lower than those in the control group （P〈0.05）;serum SOD, GSH-Px levels in the alprostadil group were higher than those in the control group （P〈0.05）.The total effective rate of diabetic nephropathy in alprostadil group （92.73%） was significantly higher than that in control group （74.55%）, the data were compared with（P〈0.05）.ConclusionIt has a positive effect on improving the therapeutic effect which alprostadil in the treatment of patients with DN, and it can relieve the inflammatory reaction and oxidative stress injury.
作者
韩俊江
HAN Jun-jiang(Department of Pharmacy, Dagang hospital, Tianjin Binhai New Area, Tianjin 500450, Chin)
出处
《中国生化药物杂志》
CAS
2017年第6期353-355,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
前列地尔
糖尿病肾病
炎症反应
氧化应激
alprostadil
diabetic nephropathy
inflammatory response
oxidative stress
作者简介
韩俊江。通信作者，男，本科，主管药师，研究方向：西药，E-mail：dingzk900@sina．com。
